Inborn disorder of bilirubin metabolism
MONDO:0017755An instance of bilirubin metabolism disease that is caused by an inherited modification of the individual's genome.
Also known as: disorder of bilirubin metabolism, disorder of bilirubin metabolism and excretion, hereditary bilirubin metabolism disease, inborn disorder of bilirubin metabolism and excretion, bilirubin metabolism disorder
39 clinical trials for this condition and its sub-types, 0 tagged with Inborn disorder of bilirubin metabolism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Inborn disorder of bilirubin metabolism
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Hereditary hyperbilirubinemia 0 trials · 18 incl. sub-types
7 sub-types
- Transient familial neonatal hyperbilirubinemia 18 trials
- Crigler-Najjar syndrome 0 trials Sub-types →
- Dubin-Johnson syndrome 0 trials
- Gilbert syndrome 0 trials
- Rotor syndrome 0 trials
- Hyperbilirubinemia, conjugated, type 3 0 trials
- Hyperbilirubinemia, shunt, primary 0 trials
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Progressive familial intrahepatic cholestasis 16 trials · 17 incl. sub-types
16 sub-types
- Progressive familial intrahepatic cholestasis type 1 4 trials
- Progressive familial intrahepatic cholestasis type 2 4 trials
- Cholestasis, progressive familial intrahepatic, 4 2 trials
- Progressive familial intrahepatic cholestasis type 3 2 trials
- Cholestasis, progressive familial intrahepatic, 5 1 trial
- Cholestasis, progressive familial intrahepatic, 6 1 trial
- Hereditary North American Indian childhood cirrhosis 1 trial
- MYO5B-related progressive familial intrahepatic cholestasis 0 trials
- Benign recurrent intrahepatic cholestasis type 1 0 trials
- Cholestasis, progressive familial intrahepatic, 10 0 trials
- Cholestasis, progressive familial intrahepatic, 11 0 trials
- Cholestasis, progressive familial intrahepatic, 12 0 trials
- Cholestasis, progressive familial intrahepatic, 13 0 trials
- Cholestasis, progressive familial intrahepatic, 7, with or without hearing loss 0 trials
- Cholestasis, progressive familial intrahepatic, 8 0 trials
- Cholestasis, progressive familial intrahepatic, 9 0 trials
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Benign recurrent intrahepatic cholestasis 2 trials · 5 incl. sub-types
2 sub-types
- Benign recurrent intrahepatic cholestasis type 2 0 trials · 4 incl. sub-types Sub-types →
- Benign recurrent intrahepatic cholestasis type 1 0 trials
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Bilirubin encephalopathy 3 trials
1 sub-type
- Kernicterus due to isoimmunization 0 trials
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2 sub-types
Most studied deeper sub-types
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Can a bile acid blocker ease severe itching in a rare liver disease?
Disease control Expanded access (ended)This expanded access program offers the experimental drug odevixibat to people with progressive familial intrahepatic cholestasis (PFIC) who have severe itching and high bile acid levels but cannot join the main clinical trial. The drug works by blocking a bile acid transporter i…
Sponsor: Albireo • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Less fat, better brains: study tests lipid reduction to protect preemies
Disease control OngoingThis study tests whether giving extremely preterm babies less intravenous (IV) fat (lipids) can lower harmful bilirubin levels and protect their brain development. Bilirubin can build up in these tiny infants and cause hearing loss or long-term disabilities. Researchers will comp…
Phase 2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Could a simple hat make jaundice treatment kinder for newborns?
Symptom relief By invitation onlyThis study tests whether a special hat with built-in goggles can make phototherapy more comfortable for full-term newborns with jaundice, compared to standard eye patches. Researchers will measure the babies' comfort levels, bilirubin changes, treatment duration, and parental sat…
Sponsor: Karamanoğlu Mehmetbey University • Aim: Symptom relief
Last updated Aug 07, 2026 00:00 UTC
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New study analyzes Odevixibat's impact on rare liver disease outcomes
Knowledge-focused OngoingThis study looks at a rare liver disease called PFIC, which causes severe itching and liver damage. Researchers compare patients who took the drug odevixibat to those who did not, using data from past studies and a patient registry. The goal is to see if odevixibat helps avoid li…
Sponsor: Ipsen • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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Major study on rare childhood liver diseases halted
Knowledge-focused PausedThis study followed children and young adults with genetic liver diseases that cause bile buildup. The goal was to track how these diseases progress over time, including the need for liver transplants or other complications. No treatments were tested; the aim was simply to learn …
Sponsor: Arbor Research Collaborative for Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Tiny sensors could revolutionize jaundice treatment for newborns
Knowledge-focused OngoingThis study tests a new wireless sensor that continuously measures the light dose babies receive during phototherapy for jaundice. Currently, doctors check light levels only once a day with a handheld device, which can be inaccurate. The sensor aims to provide real-time data to en…
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC