Immunodeficiency disease
MONDO:0021094Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Also known as: immuno-deficiency, immunodeficiency, immunodeficiency disorder, immunodeficiency syndrome
776 clinical trials for this condition and its sub-types, 55 tagged with Immunodeficiency disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Immunodeficiency disease
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T-cell immunodeficiency 4 trials · 484 incl. sub-types
3 sub-types
- AIDS 463 trials
- Congenital T-cell immunodeficiency 0 trials · 13 incl. sub-types Sub-types →
- Idiopathic CD4-positive T-lymphocytopenia 6 trials
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B cell deficiency 5 trials · 85 incl. sub-types
5 sub-types
- Agammaglobulinemia 16 trials · 52 incl. sub-types Sub-types →
- Hyperimmunoglobulin syndrome 0 trials · 33 incl. sub-types Sub-types →
- Selective immunoglobulin deficiency disease 1 trial · 4 incl. sub-types Sub-types →
- PAX5-related B lymphopenia and autism spectrum disorder 0 trials
- Immunoglobulin beta deficiency 0 trials
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Combined immunodeficiency 3 trials · 57 incl. sub-types
33 sub-types
- Severe combined immunodeficiency 24 trials · 37 incl. sub-types Sub-types →
- Ataxia telangiectasia 11 trials Sub-types →
- Wiskott-Aldrich syndrome 10 trials
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia 2 trials
- Combined immunodeficiency due to CRAC channel dysfunction 1 trial Sub-types →
- Combined immunodeficiency due to ZAP70 deficiency 1 trial
- Non-SCID combined immunodeficiency 0 trials · 1 incl. sub-types Sub-types →
- IRF4-related combined immunodeficiency 0 trials
- MHC class I deficiency 0 trials Sub-types →
- NFATC1-related combined immunodeficiency 0 trials
- POLD3-related combined immunodeficiency 0 trials
- RAC2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome 0 trials Sub-types →
- Autosomal dominant combined immunodeficiency due to ERBIN deficiency 0 trials
- Autosomal dominant combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to IL6R deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Combined immunodeficiency due to CD3gamma deficiency 0 trials
- Combined immunodeficiency due to CTPS1 deficiency 0 trials
- Combined immunodeficiency due to GINS1 deficiency 0 trials
- Combined immunodeficiency due to MALT1 deficiency 0 trials
- Combined immunodeficiency due to OX40 deficiency 0 trials
- Combined immunodeficiency due to POLE2 deficiency 0 trials
- Combined immunodeficiency due to RELA haploinsufficiency 0 trials
- Combined immunodeficiency due to STK4 deficiency 0 trials
- Combined immunodeficiency due to TBX1 deficiency 0 trials
- Combined immunodeficiency due to dimerization defective IKAROS mutation 0 trials
- Combined immunodeficiency due to moesin deficiency 0 trials
- Combined immunodeficiency syndrome 0 trials Sub-types →
- Combined immunodeficiency with low Ig due to BCL10 deficiency 0 trials
- Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to IKBKA deficiency 0 trials
- Early-onset combined immunodeficiency with low ig due to dominant negative IKAROS mutation 0 trials
- Late-onset combined immunodeficiency due to ICOSL deficiency 0 trials
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Complement deficiency 2 trials · 28 incl. sub-types
8 sub-types
- Atypical hemolytic-uremic syndrome 19 trials Sub-types →
- Classic complement early component deficiency 0 trials · 7 incl. sub-types Sub-types →
- Disorder of lectin complement activation pathway 0 trials · 1 incl. sub-types Sub-types →
- Complement factor I deficiency 0 trials
- Complement receptor deficiency 0 trials
- Immunodeficiency due to a classical component pathway complement deficiency 0 trials Sub-types →
- Immunodeficiency due to a late component of complement deficiency 0 trials Sub-types →
- Recurrent Neisseria infections due to factor D deficiency 0 trials
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X-linked lymphoproliferative syndrome 7 trials · 11 incl. sub-types
2 sub-types
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GATA2 deficiency with susceptibility to MDS/AML 5 trials · 8 incl. sub-types
2 sub-types
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Idiopathic CD4 lymphocytopenia 7 trials
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IKBKG-related immunodeficiency with or without ectodermal dysplasia 0 trials · 4 incl. sub-types
3 sub-types
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IRF4-related immune disorder 1 trial
2 sub-types
- IRF4-related combined immunodeficiency 0 trials
- Immunodeficiency 131 0 trials
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Immunodeficiency 23 1 trial
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Immunodeficiency 31B 1 trial
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DOCK2 deficiency 0 trials
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FADD-related immunodeficiency 0 trials
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FASLG-related immunodeficiency 0 trials
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FNIP1-associated syndrome 0 trials
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Shwachman-Diamond syndrome 1 0 trials
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TNFRSF9-related immunodeficiency 0 trials
1 sub-type
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Wiskott-Aldrich syndrome 2 0 trials
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Hatipoglu immunodeficiency syndrome 0 trials
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Hypoproteinemia, hypercatabolic 0 trials
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Immunodeficiency 102 0 trials
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Immunodeficiency 112 0 trials
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Immunodeficiency 117 0 trials
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Immunodeficiency 118 0 trials
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Immunodeficiency 119 0 trials
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Immunodeficiency 122 0 trials
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Immunodeficiency 125 0 trials
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Immunodeficiency 127 0 trials
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Immunodeficiency 128 0 trials
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Immunodeficiency 132b 0 trials
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Immunodeficiency 15a 0 trials
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Immunodeficiency 35 0 trials
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Immunodeficiency 45 0 trials
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Immunodeficiency 53 0 trials
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Immunodeficiency 57 0 trials
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Immunodeficiency 60 0 trials
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Immunodeficiency 62 0 trials
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Immunodeficiency 64 0 trials
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Immunodeficiency 66 0 trials
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Immunodeficiency 67 0 trials
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Immunodeficiency 69 0 trials
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Immunodeficiency 70 0 trials
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Immunodeficiency 75 0 trials
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Immunodeficiency 76 0 trials
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Immunodeficiency 77 0 trials
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Immunodeficiency 81 0 trials
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Immunodeficiency 84 0 trials
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Immunodeficiency 85 and autoimmunity 0 trials
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Immunodeficiency 86 0 trials
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Immunodeficiency 87 and autoimmunity 0 trials
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Immunodeficiency 88 0 trials
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Immunodeficiency 89 and autoimmunity 0 trials
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Immunodeficiency 92 0 trials
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Immunodeficiency 95 0 trials
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Immunodeficiency 96 0 trials
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Lymphoproliferative syndrome 1 0 trials
Most studied deeper sub-types
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Gentler transplant shows promise for kids with blood diseases
Disease control CompletedThis study tests a milder chemotherapy and immune-suppressing regimen before a stem cell transplant for children and young adults with non-malignant blood disorders like sickle cell disease or immune deficiencies. The goal is to safely achieve donor cell engraftment with fewer si…
Phase 2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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New RSV shot shows promise for vulnerable babies
Disease control CompletedThis study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…
Phase 3 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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HIV patients get hepatitis a vaccine: does it work?
Disease control CompletedThis study looked at how safe and effective a hepatitis A vaccine is for people with HIV, aged 1 to 50. About 392 participants received two vaccine doses six months apart. Researchers checked their blood for antibodies and tracked any side effects for a month after each dose. The…
Phase 4 • Sponsor: LiuZhou People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Can higher doses and steroids beat TB in HIV patients?
Disease control CompletedThis study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a …
Phase 3 • Sponsor: ANRS, Emerging Infectious Diseases • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Can Omega-3 and black seed oil help beat COVID-19?
Disease control CompletedThis completed trial tested whether natural supplements like omega-3, black seed oil, Indian costus, and quinine could boost the immune system of 150 COVID-19 patients. Participants had mild to moderate symptoms and were monitored for recovery time, fever, lung inflammation, and …
Phase 2/3 • Sponsor: Beni-Suef University • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Scientists hunt for allergy genes in massive screening study
Knowledge-focused CompletedThis study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Scientists gather clues on mysterious immune defects
Knowledge-focused CompletedThis study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Obesity may affect immune drug dosing – study seeks answers
Knowledge-focused CompletedThis study investigates how obesity affects the way the body processes intravenous immune globulin (IVIG), a treatment for immune deficiencies. Researchers measured body composition and blood levels of IVIG in 40 obese and normal-weight patients to find the best dosing strategy. …
Sponsor: Rutgers, The State University of New Jersey • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Extreme running may temporarily weaken immune system, study suggests
Knowledge-focused CompletedThis study looked at whether running an ultratrail (a very long race) raises the risk of getting an infection afterward. Researchers followed 471 runners and their companions, asking about symptoms like fever, sore throat, and fatigue for three weeks after the race. The goal was …
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC