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Extreme running may temporarily weaken immune system, study suggests

NCT ID NCT06089174

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de la Réunion Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether running an ultratrail (a very long race) raises the risk of getting an infection afterward. Researchers followed 471 runners and their companions, asking about symptoms like fever, sore throat, and fatigue for three weeks after the race. The goal was to see if the immune system's temporary dip after extreme exercise leads to more infections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If confirmed, this could help runners and doctors better understand when to watch for infections after extreme races.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, only suggest a link.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

471 people

The number who actually took part.

Started

Oct 2023

Finished

Nov 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \> 18 years * Participating in a Grand Raid de la Réunion 2023 race (Mascareignes, Trail de Bourbon, Diagonale des Fous) * Have a companion living under the same roof during the week preceding the race and the 21 days following the race and who agrees to answer the questionnaires * Do not object to the research Exclusion Criteria: * Do not understand French * A protected adult (guardianship or curatorship) or under court protection

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Conditions

The condition(s) this trial relates to.

immunodeficiency disease inborn error of immunity Infections infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Immune deficiency Infections Running

Contacts and locations

Locations

  • CHU Réunion

    Saint-Denis, 97400, Reunion

More trials for these conditions

Other studies related to the condition(s) this trial covers.