Hypoparathyroidism
MONDO:0001220Hypoparathyroidism is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.
Also known as: hypoparathyroidism, idiopathic (subtype), parathyroid, underactivity of
68 clinical trials for this condition and its sub-types, 46 tagged with Hypoparathyroidism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hypoparathyroidism
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Hereditary hypoparathyroidism 0 trials · 26 incl. sub-types
3 sub-types
- Familial hypoparathyroidism 0 trials · 10 incl. sub-types Sub-types →
- Pseudohypoparathyroidism 8 trials · 9 incl. sub-types Sub-types →
- Autoimmune polyendocrine syndrome type 1 8 trials
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Autoimmune hypoparathyroidism 0 trials · 8 incl. sub-types
1 sub-type
Most studied deeper sub-types
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Glowing goggles could prevent calcium crash after thyroid surgery
Disease control Not yet recruitingThis study tests whether a wearable goggle system that makes parathyroid glands glow can help surgeons find and protect them during thyroid removal. About 280 adults having thyroid surgery will take part. The goal is to reduce the risk of low calcium levels after surgery, a commo…
Sponsor: Ss. Cyril and Methodius University of Skopje • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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A routine calcium reading could reveal how sick a sepsis patient really is
Knowledge-focused Not yet recruitingResearchers at Assiut University are studying whether ionized calcium levels, measured from a routine blood sample when a patient enters the ICU, can signal how severe sepsis or septic shock is. The study follows 160 adults admitted to intensive care within 24 hours of presentati…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Greek study aims to better measure Hypoparathyroidism's impact
Knowledge-focused Not yet recruitingThis study will translate and test two questionnaires (HPES-Symptom and HPES-Impact) for Greek-speaking adults with chronic hypoparathyroidism. Researchers will enroll 200 patients across several hospitals in Greece. The goal is to ensure the questionnaires accurately capture pat…
Sponsor: Aristotle University Of Thessaloniki • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:55 UTC