Hypertriglyceridemia

This trial tests whether two moderate low-carbohydrate diets, one higher in protein and one higher in fat, improve blood sugar, blood fats, and weight more than a standard diet. Adults with type 2 diabetes, high triglycerides, and overweight or obesity will follow one of the thre…

This Phase 2 trial tests the long-term safety and effectiveness of HRS-7249, an investigational injection that targets a protein called APOC3 to lower triglycerides. The study includes people who previously took part in an earlier HRS-7249 trial, plus new participants aged 18 to …

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This Phase 3 trial tests an investigational biologic called DR10624, given as a weekly injection, in adults with severe hypertriglyceridemia (very high blood fats) who are already on standard lipid-lowering therapy. The study compares two doses of DR10624 against a placebo to see…

This phase 3 trial tests an investigational injectable drug called DR10624 in adults with severe hypertriglyceridemia (very high blood fats) that remains high despite standard treatment. Participants continue their usual omega-3 therapy and receive weekly injections of DR10624 or…

This early study tests a new gene-editing treatment called CS-121 in 15 adults with severe high triglycerides (a type of fat in the blood) that hasn't been controlled by standard treatments. The therapy uses tiny fat particles to deliver a gene editor that targets the APOC3 gene …

This early-stage study tests a new medicine called ISH0688, given as a shot under the skin, for people with high triglycerides (a type of blood fat). The study will involve 104 healthy volunteers and people with high triglycerides to check the drug's safety and how the body proce…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

This study investigates how eating three high-fat meals in a row changes vitamin E levels in the blood. Researchers will compare people with normal blood fats to those with high blood fats (hyperlipidemia). The goal is to understand whether fats in the blood can trap vitamin E, p…

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…