Hyperparathyroidism
MONDO:0001741Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.
Also known as: hyperparathyroidism
91 clinical trials for this condition and its sub-types, 8 tagged with Hyperparathyroidism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hyperparathyroidism
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Primary hyperparathyroidism 23 trials · 56 incl. sub-types
1 sub-type
- Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types Sub-types →
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Hereditary hyperparathyroidism 1 trial · 35 incl. sub-types
2 sub-types
- Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types Sub-types →
- Hyperparathyroidism, transient neonatal 0 trials
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Secondary hyperparathyroidism 19 trials · 32 incl. sub-types
2 sub-types
- Secondary hyperparathyroidism of renal origin 7 trials · 18 incl. sub-types Sub-types →
- Non-renal secondary hyperparathyroidism 0 trials
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Tertiary hyperparathyroidism 2 trials
Most studied deeper sub-types
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Surgery may boost bone health in kidney transplant patients with stubborn high calcium
Disease control Recruiting nowThis study compares parathyroid surgery to standard monitoring in 85 kidney transplant recipients who still have high calcium and parathyroid hormone levels. The goal is to see if surgery improves bone density, physical function, and quality of life over 12 months. Participants a…
Sponsor: Aarhus University Hospital • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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Massive study aims to unlock secrets of parathyroid diseases
Knowledge-focused Recruiting nowThis study follows up to 3,000 people who have, are at risk for, or are related to someone with a parathyroid disorder. Researchers will collect medical records, questionnaires, and samples like blood and saliva to learn what causes these conditions and how they change over time.…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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Parathyroid surgery may boost mobility in seniors
Knowledge-focused Recruiting nowThis study looks at whether removing the parathyroid gland can improve physical function and mobility in adults aged 60 and older with primary hyperparathyroidism. Researchers will track changes in walking, strength, and daily activity before and after surgery, and analyze blood …
Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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No treatment here: scientists Double-Check their own lab methods
Knowledge-focused Recruiting nowThis study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…
Sponsor: Bettina Mittendorfer • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC