Hyperinsulinism

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This large observational study looks at health records from general practitioners in Naples to estimate how common insulin resistance is in the local population. It also examines whether people with insulin resistance have a higher rate of cardiovascular disease compared to those…

This study tested whether a special fiber supplement changes intestinal gas production over 36 hours in 29 adults. Participants included lean healthy people and those with insulin resistance or prediabetes who were overweight. Researchers measured gas levels, energy use, and gut …

This study tested whether tagatose, a low-calorie sweetener, can act as a prebiotic—meaning it selectively feeds beneficial gut bacteria and improves blood sugar control. Fifty-nine healthy adults with slightly high blood sugar or insulin resistance took either tagatose or a plac…

This completed Phase 1 study from Columbia University enrolled 18 overweight or obese adults with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Researchers used a technique called a pancreatic clamp to carefully control insulin levels and measure how blood sug…

This study tested whether a drug called diazoxide, which lowers high insulin levels, can help researchers understand how fatty liver disease develops. Twenty-four adults with overweight or obesity and insulin resistance took either a low or high dose of diazoxide or a placebo for…

This study looked at whether immune cells from healthy people can affect how the body responds to insulin. Researchers took blood samples from 30 volunteers and tested how their immune cells influenced insulin signaling in liver cells in the lab. The goal was to better understand…

This study looked at whether eating fewer carbohydrates could help people with type 1 diabetes become more sensitive to insulin and improve blood vessel health. Fourteen adults on insulin pumps tried both a low-carb diet and a standard diet for one week each. The results showed n…