Huntington disease and related disorders

This trial tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in people with spinocerebellar ataxia type 3, a genetic condition that affects coordination and balance. The stimulation targets a deep brain region involved i…

This trial tests whether deep brain stimulation (DBS) targeting the cerebellum is safe and feasible for people with spinocerebellar ataxia types 1 and 3, a group of inherited disorders that cause progressive problems with movement and coordination. The study will enroll 12 adults…

This Phase 2 trial tests whether umbilical cord stem cells can safely improve movement and coordination in people with spinocerebellar ataxia (types 1, 2, 3, and 6). Forty-five participants will receive the cells through an IV and a spinal injection. The main goal is to see if sy…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This early-stage study will give 8 healthy men a single radioactive dose of LPM3770164, a drug being developed for Huntington disease. Researchers will measure how much of the drug is recovered in urine and stool, and identify its breakdown products. The goal is to understand how…

This study looks at how Huntington's disease impacts autobiographical memory—the ability to recall personal experiences and imagine future events. Researchers will use eye-tracking and neuropsychological tests in 80 participants (patients and healthy controls) to find markers of …

This study aims to see if wearable sensors and digital health tools can accurately track symptoms of Huntington's disease over 12 months. About 75 adults with and without Huntington's will wear sensors on their wrist, ankle, and pendant to measure daily activity, and complete spe…