Human papilloma virus infection

This trial tests whether the 9-valent HPV vaccine (V503) can trigger a strong immune response against nine HPV types in Chinese females aged 10 to 45 who previously received the bivalent (2-type) HPV vaccine. Participants will receive either the 9-valent vaccine or a placebo, and…

This trial tests whether the 9-valent HPV vaccine is safe and triggers a protective immune response in adults with HIV. People with HIV face higher risks of HPV infection and related cancers, but vaccine research in this group is limited. The study enrolls 60 HIV-infected adults …

This study will enroll 18,000 female university students to see if a vaccine chatbot and scientific videos can increase HPV vaccination rates. Participants are split into four groups: chatbot plus videos, chatbot only, videos only, or no intervention. The goal is to improve aware…

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

This study looks at whether giving women living with HIV the option to collect their own HPV test samples at home or in their community, with help from health workers, increases how many get screened for cervical cancer. About 17,700 women will take part across multiple clinics. …

This study tests whether a self-applied cream (5-fluorouracil) after a heat procedure (thermal ablation) can clear HPV better than a placebo cream in 140 women with HIV in Kenya. Participants will use the cream every two weeks for 24 weeks and be followed for 48 weeks total. The …

This early-stage trial tests a topical ointment called ACU-D1 for HPV-related vulvar and perianal lesions in people with HIV. Nine participants will apply the cream twice daily for 4 weeks. The main goal is to find the safest dose and see if the treatment can boost immune markers…

This trial is testing whether a vaginal gel called Papilozumib, used alone or with an oral supplement, can help restore the cervical lining in women aged 30 to 50 who have an HPV infection. Participants will be randomly assigned to receive the gel, the gel plus supplement, or sta…

This study tests an experimental injection called BBM-C101 in 200 people with persistent HPV16 or HPV18 infection and low-grade precancerous lesions of the cervix, vulva, vagina, or anus. Participants receive four shots under the skin over three weeks. The trial monitors safety a…

This study tests whether a daily oral supplement containing green tea extract (EGCG), folic acid, vitamin B12, and hyaluronic acid can help women clear a persistent human papillomavirus (HPV) infection. HPV is a common virus that can cause cervical cancer if it stays in the body …

This study tests a new approach for treating high-grade cervical precancer (HSIL) using a cream called HAL that is activated by a special light, instead of standard surgery. About 230 women will be randomly assigned to receive either the light therapy or surgery. The main goal is…

This early-phase trial tests whether a new drug (ATRN-119) combined with a single, precise dose of radiation to the neck can safely and effectively treat early-stage HPV-positive throat cancer before surgery. About 35 participants will take the drug daily for 10 days and receive …

This early-stage trial tests an injection called BBM-C101 in 60 women with high-grade cervical precancer linked to HPV16 or HPV18. The goal is to see if the drug is safe and can shrink or eliminate abnormal cells, potentially offering a non-surgical alternative. Participants rece…

This early-stage study tests a new drug called NWRD09 in 78 women aged 18-60 who have had a persistent HPV16 infection for at least 6 months. The goal is to see if the injection is safe and can help the body clear the virus. Participants will receive either the drug or a placebo,…

This study compares a non-invasive ultrasound treatment (HIFU) to standard observation for low-grade cervical lesions (LSIL/CIN1) in 180 pre-menopausal women. Most of these lesions go away on their own, but the trial aims to see if HIFU can speed up clearance of the lesion and th…

This phase 2 trial tests whether a single dose of the HPV vaccine (Gardasil-9) can reduce the infectivity of high-risk HPV in women aged 18-29 who already have the virus. Researchers will compare cervical samples from vaccinated and unvaccinated women at 6 months to see if vaccin…

This study tests whether a daily dietary supplement containing EGCG (from green tea), vitamin B12, hyaluronic acid, and folic acid can help men with HPV maintain genital health and possibly clear the virus. The trial will include 96 participants (48 couples) and compare those tak…

This pilot study tests whether a daily dietary supplement containing EGCG, folic acid, vitamin B12, and hyaluronic acid can help men clear an active HPV infection and improve sperm health. The study involves 34 couples trying to conceive, where the male partner has HPV and the fe…

This study tests a treatment called photodynamic therapy (PDT) for women with low-grade cervical precancer caused by HPV types 16 or 18. A photosensitizing cream is applied to the cervix, then activated with light to destroy abnormal cells. The trial will compare 225 women who re…

This study compares a light-activated gel treatment (ALA-PDT) to standard surgery (LEEP) for women with high-grade cervical precancer (HSIL/CIN2). About 560 women will receive either the gel plus red light therapy or surgery. The goal is to see if the gel treatment works as well …

This study tests whether special MRI scans can predict how well HPV-positive throat cancer responds to standard chemotherapy and radiation. Researchers will scan 30 adults before treatment and track their outcomes. The goal is to see if MRI patterns can identify low-risk patients…

This study is testing whether human papillomavirus (HPV) can be accurately detected from menstrual blood collected at home. Participants who had a routine HPV test within the past 90 days will use a special kit to collect a menstrual blood sample. The results will be compared wit…

This trial is testing whether the GeneXpert system, a portable device that can run multiple tests, can accurately detect HIV, chlamydia, gonorrhea, hepatitis C, and HPV in community health centers and clinics. Researchers will compare its results to standard lab tests and track w…

This study aims to see if a simple blood test can find HPV-related oropharyngeal cancer early in men aged 50 and older who have no symptoms. Researchers will check blood for two markers of HPV and then follow up with those who test positive to find and treat any tumors. If succes…

The PRIORITY study is testing a new approach to diagnose cervical cancer earlier by combining self-sampling at home with digital colposcopy and telemedicine. Researchers will enroll 700 women aged 30 to 65 to see if this method is more accurate and faster than current care. The g…

Researchers are testing whether a quadrivalent HPV vaccine can be given at the same time as a tetanus-diphtheria booster in healthy children and adolescents aged 9 to 15 in Indonesia. The trial compares children who receive both vaccines together with those who receive the HPV va…

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

HPV vaccines can prevent thousands of cancer cases each year, but many children do not get them. Researchers at the University of Florida test whether a tablet app called Protect Me 4 helps parents and doctors talk about the vaccine and decide to give it. The trial enrolls parent…

This study tests a program to help parents in rural Kentucky feel more confident about the HPV vaccine for their teens. About 58 vaccine-hesitant mothers or female guardians will use a web app with short videos and then talk to their child's doctor, who will use special prompts. …

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is …

This study tests whether using two heat probes instead of one can better prevent cervical cancer in women living with HIV, who face a much higher risk. Researchers will enroll 300 women in Kenya to see if the two-probe method is safe, acceptable, and more effective at clearing HP…

This study tests whether an AI chatbot can help women aged 15 to 26 in China feel more confident about getting the HPV vaccine. About 1800 participants will be split into two groups: one gets access to the chatbot, the other does not. Researchers will compare vaccination rates an…

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study checks if testing for high-risk HPV before a subtotal hysterectomy can help prevent cervical cancer. About 300 women scheduled for this surgery will get an HPV test; if positive, they will have a cone biopsy to remove any precancerous cells during the same operation. T…

This study will enroll 18,000 parents of junior high school girls to see if a vaccine chatbot can boost HPV vaccination rates. Parents are split into four groups: chatbot plus videos, chatbot only, videos only, or no intervention. The goal is to improve vaccine awareness, intenti…

This study will test whether a three-session educational program for mothers of children aged 9-15 can improve their knowledge about HPV and increase their willingness to vaccinate their children. One hundred mothers will be randomly assigned to either the education program or st…

This study continues a community project in rural Kenya to prevent cervical cancer. It offers the 9-valent HPV vaccine to 2000 adolescent girls and tests self-collected swabs for high-risk HPV in adult women. Researchers will also study why some families do not participate and wh…

This study is for people with HPV-related oropharyngeal (throat) cancer, which often responds well to treatment. The goal is to see if lowering the radiation dose to certain areas can reduce side effects like dry mouth without hurting the chance of curing the cancer. About 132 pa…

This study looks at how to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore using HPV self-testi…

This trial tests whether people living with HIV can collect their own anal swabs for anal cancer screening, compared with swabs taken by a clinician. About 700 participants in Australia will provide both types of swabs, which will be checked for high-risk HPV and precancerous cel…

This study explores whether a text-message education program and a mail-in HPV self-sampling kit can help women living with HIV who are overdue for cervical cancer screening get tested. Researchers will enroll 130 women and healthcare providers to see if the approach is practical…

This study will see if offering HPV self-sampling kits in emergency departments can help women who are overdue for cervical cancer screening. About 100 women in New Jersey will be given a kit and education during their ER visit. Those who test positive for HPV will be guided to f…

This study compares two fun, game-based ways to teach nursing students about HPV. One group plays a digital quiz game (Gimkit), while the other works together in an escape room. Researchers will measure how much students learn and remember after one month. The goal is to find bet…

This study tests a new website designed to help 11-12 year olds and their parents learn about the HPV vaccine. The goal is to see if the tool is easy to use and helpful in real school settings, especially in areas where fewer people get vaccinated. About 100 students and their fa…

This study looks at whether a web-based education program can improve women's attitudes and beliefs about HPV testing, which is key for preventing cervical cancer. About 120 women aged 18-60 will take part, with half receiving the online education and the other half getting stand…

This study looks at better ways to screen for HPV and prevent cervical cancer in women living with HIV. Researchers will test a new method that identifies specific HPV types and viral load. The goal is to see if this approach is practical for a larger future study. About 750 wome…

This study is testing a comprehensive program to help adolescent girls aged 9-17 and their parents make informed decisions about the HPV vaccine. The program includes educational materials, shared decision-making conversations, and reminders. Researchers will compare vaccination …

This study will test whether a specially designed card game can improve knowledge and health beliefs about HPV in hearing-impaired adults. Forty participants will be randomly assigned to play the card game or receive standard education. The goal is to see if this fun, visual meth…