Hereditary lipodystrophy
MONDO:0020087An instance of lipodystrophy that is caused by an inherited genomic modification in an individual.
Also known as: genetic lipodystrophy, genetic lipodystrophy (disease)
18 clinical trials for this condition and its sub-types, 2 tagged with Hereditary lipodystrophy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hereditary lipodystrophy
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Familial partial lipodystrophy 13 trials · 14 incl. sub-types
10 sub-types
- Familial partial lipodystrophy, Dunnigan type 4 trials
- AKT2-related familial partial lipodystrophy 0 trials
- CIDEC-related familial partial lipodystrophy 0 trials
- LIPE-related familial partial lipodystrophy 0 trials
- PLIN1-related familial partial lipodystrophy 0 trials
- PPARG-related familial partial lipodystrophy 0 trials
- Autosomal semi-dominant severe lipodystrophic laminopathy 0 trials
- Familial partial lipodystrophy, Kobberling type 0 trials
- Lipodystrophy, familial partial, type 8 0 trials
- Lipodystrophy, familial partial, type 9 0 trials
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Congenital generalized lipodystrophy 2 trials · 3 incl. sub-types
5 sub-types
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Berardinelli-Seip congenital lipodystrophy 0 trials · 1 incl. sub-types
4 sub-types
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Keppen-Lubinsky syndrome 0 trials
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SHORT syndrome 0 trials
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Wiedemann-Rautenstrauch syndrome 0 trials
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Mandibuloacral dysplasia 0 trials
2 sub-types
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New hope for rare fat disorder: experimental drug mibavademab under safety review
Disease control CompletedThis study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…
Phase 3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Old drug, new hope for right heart failure?
Disease control CompletedThis study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.
Phase 4 • Sponsor: Ottawa Heart Institute Research Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Could a simple breakfast replace the glucose drink for diabetes testing?
Diagnosis CompletedThis trial explores whether a standardized breakfast and a continuous glucose monitor can replace the traditional glucose drink test for diagnosing diabetes and prediabetes in people with Dunnigan's lipodystrophy, a rare genetic condition that causes severe insulin resistance. Th…
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Diagnosis
Last updated Aug 08, 2026 00:03 UTC
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Rare fat disorder may quietly fuel hidden inflammation
Knowledge-focused CompletedResearchers are studying whether adults with Dunnigan lipodystrophy, a rare genetic condition that changes how the body stores fat, have higher levels of inflammation than people without it. The trial enrolls 64 non-diabetic adults on Reunion Island, including those with the cond…
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Rare fat disorder gene hunt: just 2 patients could unlock answers
Knowledge-focused CompletedThis study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Researchers investigate Cortisol's role in rare fat disorder
Knowledge-focused CompletedThis study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC