HELLP syndrome
MONDO:0008585A life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems.
Also known as: hemolysis, elevated liver enzymes, low platelets in pregnancy, hemolysis-elevated liver enzymes-low platelet count syndrome, hemolysis-elevated liver enzymes-low platelets syndrome, PEE1, PREECLAMPSIA/eclampsia 1, PREG1, hemolysis, elevated liver enzymes, and low platelet count, hemolysis, elevated liver enzymes, lowered platelets
35 clinical trials for this condition and its sub-types, 13 tagged with HELLP syndrome itself.
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HELLP syndrome blood markers tracked daily in new study
Knowledge-focused CompletedThis completed study observed 72 pregnant women with HELLP syndrome in the ICU. Researchers tracked daily changes in platelets, liver enzymes, and lactate dehydrogenase before and after delivery. The goal was to understand how these biological markers evolve, not to test a treatm…
Sponsor: CHU Mohammed VI Marrakech • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Blood protein clues may predict dangerous pregnancy problems
Knowledge-focused CompletedThis study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Blood DNA levels may signal pregnancy problems
Knowledge-focused CompletedThis study measured the amount of free-floating DNA and nucleosomes in the blood of 137 women to see if these levels differ between those with pregnancy complications (like preeclampsia or blood clots) and healthy women (both pregnant and non-pregnant). The goal was to better und…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC