Gram-negative bacterial infections

This study tests a new vaccine designed to protect against four types of meningococcal bacteria that can cause serious infections like meningitis and sepsis. About 1,100 healthy adults aged 19 to 55 will receive a single dose to see how well it triggers the immune system and if i…

This study compares different antibiotic strategies for people hospitalized with Gram-negative bloodstream infections. The goal is to find which approach leads to better outcomes, like survival and fewer complications, while also reducing the risk of antibiotic resistance. About …

This study is testing the safety and how the body handles Vaborem, a combination of two antibiotics (meropenem and vaborbactam), in children from birth to under 18 years old who have serious Gram-negative bacterial infections. All 44 participants will receive the drug intravenous…

This study tests a new IV antibiotic (aztreonam-avibactam) in hospitalized children aged 9 months to 18 years with serious gram-negative bacterial infections. About 48 participants will receive either the new drug or the best available standard treatment. The goal is to see how t…

This study tests a combination of two antibiotics, aztreonam and avibactam, in newborns and infants up to 9 months old who have serious infections caused by gram-negative bacteria. The trial has two parts: one to see how a single dose moves through the body, and another to test m…

This study is testing two different ways of giving a combination of two antibiotics (ceftazidime-avibactam and aztreonam) to treat serious infections caused by bacteria that are resistant to many drugs. The researchers want to see if giving the drugs one after the other works as …

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part,…

This study tests whether adding a second antibiotic (fosfomycin) to the standard antibiotic (ceftazidime) helps people with severe gram-negative infections recover faster. About 100 hospitalized adults will be randomly assigned to get either the combo or the standard drug plus a …

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study aims to develop a predictive model for mortality in critically ill patients who carry multidrug-resistant gram-negative bacteria (MDR-GNB). Researchers will follow about 1,500 adults in intensive care units (ICUs) who are colonized with these bacteria, tracking their i…

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

This study tests whether a rapid lab test can help doctors choose the right antibiotic sooner for patients with bloodstream infections. About 400 adults with positive blood cultures will be randomly assigned to either the rapid test or standard testing. The goal is to see if the …

This observational study is looking at how two antibiotics, ceftazidime/avibactam and fosfomycin, work in the body to treat infections caused by carbapenem-resistant Enterobacterales (CRE), a type of superbug. Researchers will monitor 60 adult patients to see if the drug levels i…

This study looks at how the antibiotic cefiderocol behaves in the bodies of people with severe burns. Researchers want to find the best dose to kill bacteria and prevent resistance. The study will enroll 12 adults with burns who have good kidney function.

This study compares two strong antibiotics, polymyxin B and colistin, in treating serious infections caused by bacteria that are resistant to many common drugs. Researchers will look at medical records of 480 adults with pneumonia or bloodstream infections to see which antibiotic…