Genetic developmental and epileptic encephalopathy
MONDO:0100062A complex neurodevelopmental disorder characterized by a range of developmental delays and epileptic encephalopathy phenotypes. Seizure onset is variable and intellectual disability is variable in presence and severity.
Also known as: developmental and epileptic encephalopathy, hereditary developmental and epileptic encephalopathy
93 clinical trials for this condition and its sub-types, 2 tagged with Genetic developmental and epileptic encephalopathy itself.
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Sub-types of Genetic developmental and epileptic encephalopathy
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Dravet syndrome 39 trials
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Lennox-Gastaut syndrome 26 trials · 27 incl. sub-types
3 sub-types
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Neonatal-onset developmental and epileptic encephalopathy 0 trials · 5 incl. sub-types
20 sub-types
- Developmental and epileptic encephalopathy, 13 3 trials
- Developmental and epileptic encephalopathy, 25 1 trial
- Developmental and epileptic encephalopathy, 42 1 trial
- Developmental and epileptic encephalopathy, 12 0 trials
- Developmental and epileptic encephalopathy, 16 0 trials
- Developmental and epileptic encephalopathy, 21 0 trials
- Developmental and epileptic encephalopathy, 24 0 trials
- Developmental and epileptic encephalopathy, 26 0 trials
- Developmental and epileptic encephalopathy, 28 0 trials
- Developmental and epileptic encephalopathy, 29 0 trials
- Developmental and epileptic encephalopathy, 31A 0 trials
- Developmental and epileptic encephalopathy, 32 0 trials
- Developmental and epileptic encephalopathy, 33 0 trials
- Developmental and epileptic encephalopathy, 34 0 trials
- Developmental and epileptic encephalopathy, 39 0 trials
- Developmental and epileptic encephalopathy, 41 0 trials
- Developmental and epileptic encephalopathy, 44 0 trials
- Developmental and epileptic encephalopathy, 45 0 trials
- Developmental and epileptic encephalopathy, 46 0 trials
- Developmental and epileptic encephalopathy, 47 0 trials
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2 sub-types
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Study tests safer switch from street CBD to approved drug for kids with severe epilepsy
Disease control Not yet recruitingThis study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…
Phase 4 • Sponsor: Elizabeth Donner • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Can a slow start with CBD oil tame Hard-to-Control seizures?
Disease control Not yet recruitingThis trial tests whether a gradual dosing schedule of cannabidiol oral solution (CBD-OS) can help reduce seizures in adults with Lennox-Gastaut syndrome, a severe form of epilepsy. Participants will take CBD oil alongside their usual seizure medications. The study measures how ma…
Phase 4 • Sponsor: Jazz Pharmaceuticals • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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New drug trial aims to tame seizures in rare childhood disorder
Disease control Not yet recruitingThis study tests whether the drug ganaxolone can reduce seizures in children aged 6 months to 2 years with CDKL5 deficiency disorder, a rare genetic condition causing hard-to-control seizures. Twenty children will receive either ganaxolone or a placebo alongside their usual seizu…
Phase 3 • Sponsor: Immedica Pharma AB • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Smart brain pacemaker aims to stop seizures while you sleep
Disease control Not yet recruitingThis early study will test a new way to use deep brain stimulation (DBS) in 4 adults with Lennox-Gastaut syndrome, a severe form of epilepsy. The device will automatically adjust stimulation based on whether the person is awake or asleep. Researchers want to see if this personali…
Sponsor: University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Hot baths tested as seizure treatment for rare childhood disorder
Symptom relief Not yet recruitingThis study tests whether taking a daily hot bath (40-42°C for 20 minutes) at home can reduce epileptic seizures in children with CDKL5 deficiency disorder. The trial will include 34 children aged 6 months to 14 years whose seizures are not controlled by medication. Researchers wi…
Sponsor: Xuanwu Hospital, Beijing • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Blood markers may expose hidden brain changes in dravet syndrome
Knowledge-focused Not yet recruitingResearchers are testing whether blood samples can reveal brain damage and inflammation in people with Dravet syndrome, a severe form of epilepsy that also affects development. The study compares blood markers from 60 people with Dravet syndrome to 30 healthy controls, and follows…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Sep 05, 2026 00:00 UTC
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Do brain monitors fool seizure kids? study aims to find out
Knowledge-focused Not yet recruitingThis study will check if two common brain monitors used during anesthesia (BIS and Sedline) give accurate readings in children with severe seizure disorders. Researchers will compare these monitors to a standard EEG in 40 children under 16. The goal is to make anesthesia safer fo…
Sponsor: Telethon Kids Institute • Aim: Knowledge-focused
Last updated Jul 19, 2026 00:00 UTC
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Wearable EEG gadget aims to perfect seizure drug dosing at home
Knowledge-focused Not yet recruitingThis study tests whether a wearable device that records brain waves, heart rate, and movement at home can help doctors better adjust the dose of the seizure drug fenfluramine for people with Dravet syndrome or Lennox-Gastaut syndrome. Twenty patients will wear the device for 3-7 …
Sponsor: Byteflies • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC