Gallstones

This trial asks whether routinely taking an X-ray of the bile ducts during gallbladder removal is better than only doing it when there's a concern. It includes 6,000 patients having gallbladder surgery who have no signs of bile duct stones. The goal is to see which approach leads…

This study tests a capsule called CnU (750 mg) to see if it can dissolve cholesterol gallstones. About 484 adults with small, non-calcified gallstones will take the capsule for 24 weeks. The goal is to check if the stones shrink or disappear, and to ensure the treatment is safe.

This study is testing whether a specific diet can help people pass very small gallstones (sludge) without surgery. One hundred adults with tiny stones (less than 2 mm) will be randomly assigned to a special diet or a control diet. The main goal is to see if the diet can completel…

This study compares standard ultrasound (done on the outside of the belly) with laparoscopic ultrasound (done inside the abdomen during weight-loss surgery) to see which finds more gallstones and other gallbladder issues. The goal is to better identify patients who could benefit …

This study compares two types of gallbladder removal surgery for non-cancerous conditions like gallstones or polyps. About 276 adults will be randomly assigned to either robotic or standard laparoscopic surgery. The main goal is to see if robotic surgery is as safe as the traditi…

This study tests whether adding a gentle electrical acupoint stimulation (TEAS) to a standard three-drug anti-nausea regimen can further reduce vomiting after laparoscopic surgery. Researchers will compare active TEAS to a sham (fake) version in 780 women at high risk for postope…

This study tests whether a non-invasive device called TENS, which delivers mild electrical currents through the skin, can reduce anxiety and pain and improve satisfaction in 80 adults having laparoscopic gallbladder removal. Participants will receive either standard care or TENS …

Researchers are studying whether the mix of bacteria in the gut relates to complications of gallstone disease, such as pancreatitis and acute cholecystitis. Adults with confirmed gallstones at East Kent hospitals provide stool samples at several points, including before and after…

This study looks at whether using lung ultrasound right after gallbladder surgery can find breathing problems like collapsed lung tissue (atelectasis) early. About 110 adults having laparoscopic gallbladder removal with low-flow anesthesia will be checked. The goal is to see if e…

This study looks at how gut bacteria and body chemistry change in people who have surgery to remove gallstones. Researchers will collect stool, urine, blood, and saliva samples before and after surgery from 65 adults. The goal is to understand these changes, not to test a new tre…

This study follows 800 people with gallstones and belly pain who are scheduled for gallbladder removal surgery. Researchers will track their symptoms and quality of life before and three months after surgery. The goal is to create a simple tool that predicts who will actually get…