Fibrodysplasia ossificans progressiva

MONDO:0007606

Fibrodysplasia ossificans progressiva (FOP) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone in characteristic extraskeletal sites.

Also known as: FOP, Stone Man syndrome, Stone man syndrome, fibrodysplasia ossificans progressiva, fop, progressive myositis ossificans, myositis ossificans progressiva

10 clinical trials for this condition and its sub-types, 10 tagged with Fibrodysplasia ossificans progressiva itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Hereditary disease (18235) ↑ Skeletal system disorder (9737) ↑ Subcutaneous tissue disorder (64)

Including sub-types (10) Tagged with Fibrodysplasia ossificans progressiva (10)

Trials to join now! 4 Not yet recruiting 1 Not yet finished but already full! 4 Terminated 1

Promising antibody trial aims to halt rare bone disease in kids

Disease control Not yet recruiting

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

Phase 3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control

Last updated Aug 26, 2026 00:00 UTC

Fibrodysplasia ossificans progressiva

Where it sits in the disease tree

Promising antibody trial aims to halt rare bone disease in kids