Familial juvenile hypertrophy of the breast

MONDO:0007237

Familial juvenile hypertrophy of the breast is a rare breast malformation disorder characterized by unilateral or bilateral, symmetrical or asymmetrical, uncontrolled, rapid and massive enlargement of the breast(s) in peripubertal females, occurring in various members of a family. Additional associated manifestations may include skin hyperemia, dilated subcutaneous veins, skin necrosis, kyphosis, lordosis and anonychia. Growth and development are otherwise normal.

Also known as: familial juvenile gigantomastia, juvenile gigantomastia, juvenile macromastia, virginal breast hypertrophy, virginal mammary hypertrophy, JHB, gigantomastia, juvenile, hypertrophy of the breast, juvenile

4 clinical trials for this condition and its sub-types, 4 tagged with Familial juvenile hypertrophy of the breast itself.

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↑ Hereditary disease (18235) ↑ Breast disorder (4696)

Including sub-types (4) Tagged with Familial juvenile hypertrophy of the breast (4)

Trials to join now! 2 Not yet recruiting 1 Completed 1

A shot that might dull post-surgery pain and cut opioid use in teens

Symptom relief Completed

This trial tests whether injecting a local anesthetic called bupivacaine under the chest muscle during breast reduction surgery can lower pain and reduce the need for narcotic painkillers afterward. About 52 female patients aged 13 to 25 will be randomly assigned to receive eithe…

Phase 4 • Sponsor: Connecticut Children's Medical Center • Aim: Symptom relief

Last updated Aug 02, 2026 00:00 UTC

Familial juvenile hypertrophy of the breast

Where it sits in the disease tree

A shot that might dull post-surgery pain and cut opioid use in teens