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Familial hypercholesterolemia

MONDO:0005439

An inheritable form of hyperlipidemia, in which there are excess lipids in the blood.

Also known as: hyperlipoproteinemia type II, type II hyperlipidemia

95 clinical trials for this condition and its sub-types, 58 tagged with Familial hypercholesterolemia itself.

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Where it sits in the disease tree

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Part of

↑ Familial hyperlipidemia (130) ↑ Hyperlipoproteinemia (106)

Sub-types of Familial hypercholesterolemia

Homozygous familial hypercholesterolemia 22 trials
Hypercholesterolemia, familial, 1 19 trials
Hypercholesterolemia, autosomal dominant, 3 4 trials
Hypercholesterolemia, autosomal dominant, type B 1 trial
Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency 0 trials

Including sub-types (95) Tagged with Familial hypercholesterolemia (58)

Trials to join now! 40 Not yet recruiting 11 Not yet finished but already full! 16 Completed 27 Terminated 1

Experimental drug targets stubborn cholesterol in rare disease

Disease control Stopped early

This study tested an experimental drug called ARO-ANG3 in 18 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. Participants received injections of the drug and were monitored for safety and cholesterol change…

Phase 2 • Sponsor: Arrowhead Pharmaceuticals • Aim: Disease control

Last updated Jun 27, 2026 13:06 UTC