Familial Alzheimer disease

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This study tests a new drug called PRI-002 in 304 people with mild memory problems or early Alzheimer's. The drug aims to break apart harmful protein clumps in the brain that are linked to Alzheimer's. Researchers want to see if it is safe and can slow down memory and thinking de…

This early-stage trial tested a gene therapy called LX1001 in 15 people with Alzheimer's who have two copies of the APOE4 gene, a high-risk form. The therapy delivers a healthy APOE2 gene to try to change the course of the disease. The main goal was to check safety and side effec…

This study is working on a blood test to help diagnose Alzheimer's disease. Researchers are measuring two specific markers in the blood of 200 people—some with Alzheimer's and some healthy—to see if these markers can reliably tell the difference. The goal is to create a simple, n…

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

This study tested whether adding acupuncture to standard care can slow down memory and thinking problems in people with mild Alzheimer's disease. Researchers compared real acupuncture to a fake (sham) procedure in 160 participants to see if the effects were real or just a placebo…

This study tested whether listening to personalized music can improve thinking and daily function in people with advanced-stage Alzheimer's disease. Researchers enrolled 54 older adults and had them listen to either their favorite music or a classical piece. The goal was to see i…

This study tests whether spending less time in bed for four weeks can deepen sleep and boost memory in adults aged 65-85 who have poor sleep and are at risk for Alzheimer's. Researchers will measure brain activity, memory, and blood markers. The goal is to see if a simple behavio…

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study collected blood and DNA samples from 26 people with early-onset Alzheimer's disease and their close family members. Researchers analyzed the samples to find genetic changes and biomarkers that could help doctors diagnose, treat, and monitor the disease in the future. T…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …