Esophageal ulcer

This trial tests whether an experimental drug called JP-1366 can prevent the return of erosive esophagitis in people whose condition has already healed. About 384 adults aged 19 to 75 will take either JP-1366 or the standard drug lansoprazole daily for 24 weeks. The goal is to se…

This study tests whether a digital bottle cap called FORTISKAP™ can detect missed doses of proton pump inhibitors (PPIs) in people with GERD more accurately than standard methods like pharmacy fill records or patient questionnaires. Fifty adults with GERD who take a daily PPI wil…

This study compares two versions of a minimally invasive procedure called POEM for treating achalasia, a swallowing disorder. The standard POEM often causes severe heartburn afterward. The new version, Sling-Fiber Preserving POEM, aims to reduce that risk by leaving certain stoma…

This pilot study compares recorded gut-directed hypnosis to an educational recording for hospitalized patients with chronic gut problems, such as irritable bowel syndrome or inflammatory bowel disease. Participants listen to the recordings over the phone while in the hospital for…

Laparoscopic fundoplication relieves reflux for most GERD patients, but 10 to 30 percent still have symptoms or side effects afterward. Researchers at Minia University Hospitals follow 470 adults scheduled for this keyhole surgery, measuring ten factors before the operation such …

This study looks back at medical records from high-volume hospitals in Russia and China to compare how patients with stomach cancer or cancer at the junction of the stomach and esophagus fare after a specific surgery called proximal gastrectomy with double-tract reconstruction. R…

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…