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Erythroplakia
MONDO:0023089A clinical term that refers to the presence of a red flat and well defined lesion on the oral mucosa that is not caused by trauma, vascular, or inflammatory processes. It is a precancerous condition and is seen more commonly in middle aged or older males. It is associated with tobacco and alcohol consumption. Microscopic examination reveals severe epithelial dysplasia, carcinoma in situ, or invasive squamous cell carcinoma.
Also known as: erythroplakia
1434 clinical trials for this condition and its sub-types, 8 tagged with Erythroplakia itself.
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Glow-in-the-Dark mouth scans could catch cancer early
Diagnosis OngoingThis study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…
Sponsor: M.D. Anderson Cancer Center • Aim: Diagnosis
Last updated Sep 16, 2026 00:00 UTC
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Can a diabetes drug stop oral cancer before it starts?
Prevention OngoingThis study tests whether metformin, a common diabetes drug, can prevent oral cancer in people with precancerous white or red patches in the mouth. About 34 participants will receive either metformin or a placebo for several months. Researchers will check if the patches shrink or …
Phase 2 • Sponsor: University of Arizona • Aim: Prevention
Last updated Sep 04, 2026 00:00 UTC
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Could a common diabetes drug stop oral cancer before it starts?
Prevention OngoingThis phase 2 trial tests whether metformin, a widely used diabetes drug, can prevent oral cancer in 26 people with precancerous mouth lesions (leukoplakia or erythroplakia). Participants take metformin by mouth, and researchers check if the lesions shrink or disappear. The goal i…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Prevention
Last updated Jun 28, 2026 00:00 UTC