Enterocolitis

This pilot trial is asking whether emergency abdominal surgery for newborns with a serious gut condition called necrotising enterocolitis should be done in the operating theatre or right on the neonatal unit. It will compare outcomes like stability during surgery, wound infection…

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This study tests whether a special anti-regurgitation formula, made from extensively hydrolysed casein, is safe and well-tolerated in infants with cow's milk protein allergy (CMPA). About 55 babies aged 1 to 9 months will take part. The formula is given in a controlled food chall…

This large trial studies over 2,300 very preterm infants (born before 29 weeks) to see whether supplementing mother's milk with pasteurized donor milk or preterm formula improves survival without severe necrotizing enterocolitis (NEC), a dangerous gut condition. It also tests whe…

Researchers at Assiut University Children Hospital are measuring fecal calprotectin, a protein linked to gut inflammation, in preterm infants. The study compares levels between babies who develop necrotizing enterocolitis and those who do not, and between exclusively breastfed an…

Researchers compare two approaches to care after ileostomy reversal surgery in children. One group receives the Enhanced Recovery After Surgery (ERAS) protocol, which includes early feeding, early catheter removal, early walking, and multimodal pain control. The other group recei…

This study looks at how 'leaky' the gut is and what bacteria live in the intestines of 150 very low birth weight preterm babies. Researchers want to understand why some babies develop a life-threatening gut emergency called NEC. They will measure gut permeability using harmless s…

This study looks at whether premature infants who had necrotizing enterocolitis (NEC) are more likely to develop allergies by age 2. Researchers will compare skin prick test results between 130 infants with and without NEC. The goal is to understand if NEC affects later allergy d…

This study tests whether giving breast milk enemas to preterm babies can improve their gut bacteria and reduce complications like feeding problems. Sixty preterm infants will receive either breast milk or saltwater enemas for five days. The goal is to see if this simple approach …

This study aims to create an early warning system for necrotizing enterocolitis (NEC), a severe gut emergency in preterm infants. Researchers will analyze genetic and immune markers from 1,050 babies born before 32 weeks to identify those at highest risk. The goal is to improve e…

This study will watch and record information from 120 newborns with serious gut problems admitted to the NICU. Researchers will track what types of emergencies are most common, how long babies stay in the hospital, and how many need surgery. The goal is to better understand these…