Endogenous depression

This study tested magnetic seizure therapy (MST) in 239 adults with treatment-resistant depression to see if it works as well as electroconvulsive therapy (ECT) but with fewer memory side effects. MST uses magnetic pulses to trigger a controlled seizure, aiming to relieve depress…

This study looked at whether bright light therapy helps depression equally well in spring/summer compared to autumn/winter. Over 200 adults with depression received daily 30-minute light sessions for at least a week. Researchers measured symptom changes and followed up for three …

This study looked at whether adding pramipexole (a drug used for Parkinson's) for 6 months can safely reduce anhedonia — the loss of pleasure or interest — in people with depression. 55 adults who had already been in a shorter trial took pramipexole alongside their usual treatmen…

This study tested a personalized form of brain stimulation for people with depression who no longer feel pleasure (anhedonia). Sixty adults received either individualized, standard, or fake magnetic pulses to the brain over one week. The goal was to see if tailoring the stimulati…

This study tested a non-invasive brain stimulation technique called iTBS for treating depression. 73 adults with moderate depression received either real or sham (placebo) stimulation daily for two weeks. Researchers measured changes in mood, thinking skills, and brain scans to s…

This pilot study tested whether pramipexole, a drug used for Parkinson's disease, could help people with depression who struggle with anhedonia—the inability to feel pleasure or motivation. Thirteen adults with depression and significant anhedonia took pramipexole alongside their…

This study tested whether trained peer specialists—Veterans who have faced similar challenges—could help other Veterans at high risk for suicide. Over three months, 17 Veterans received one-on-one support focused on building hope, connection, and a sense of purpose. Researchers m…

This study tested a non-medication sleep program for 88 adults with depression, bipolar disorder, or ADHD who also had insomnia. Participants received either the sleep program or standard sleep hygiene advice. The goal was to see if the program could improve sleep quality and red…

This study tested whether using a virtual reality (VR) headset to do fun activities could help ease depression symptoms. 26 adults with major depression were asked to complete at least four activities each week, either in VR or in real life. Researchers measured changes in depres…

This study tested whether real-time brain scans (fMRI) could help people with major depression learn to stop focusing on negative thoughts. 71 adults received either active or sham neurofeedback while doing a task. The goal was to see if changing brain patterns could reduce depre…

This study tested whether a generic selegiline skin patch works the same as the brand-name EMSAM patch. Twelve healthy adults wore both patches to measure how much drug got into their blood and to check for skin irritation. The goal was to see if the generic version is a safe and…