Endogenous Cushing syndrome
MONDO:0957431Any Cushing syndrome caused by body's prolonged overproduction of cortisol that can be dependent on or independent of adrenocorticotropic hormone (ACTH).
Also known as: endogenous CS
40 clinical trials for this condition and its sub-types, 3 tagged with Endogenous Cushing syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Endogenous Cushing syndrome
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ACTH-dependent Cushing syndrome 23 trials · 26 incl. sub-types
2 sub-types
- Cushing disease due to pituitary adenoma 23 trials
- Ectopic Cushing syndrome 1 trial
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ACTH-independent Cushing syndrome 9 trials · 11 incl. sub-types
Most studied deeper sub-types
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Can a stronger radiation dose fix hormone overload?
Disease control Not yet recruitingResearchers are testing whether a higher dose of proton beam therapy can normalise hormone levels better than standard radiotherapy in people with functioning pituitary tumours, including acromegaly and Cushing's disease. Participants receive about six weeks of either standard-do…
Phase 3 • Sponsor: University College, London • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Could a drug tame excess cortisol in a common hormone disorder?
Disease control Not yet recruitingThis study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New scan could spot invisible brain tumors
Diagnosis Not yet recruitingThis study tests whether a special PET scan (18FET) can find small pituitary tumors that standard MRI scans miss. About 30 adults with suspected hormone-secreting pituitary tumors will receive the scan. If it works, it could help doctors decide on surgery or radiation without nee…
Phase 2 • Sponsor: University Hospital, Lille • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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Tiny trial to see if a dye helps adrenal surgery
Knowledge-focused Not yet recruitingThis study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…
Sponsor: University of Roma La Sapienza • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC