Early-onset autosomal dominant Alzheimer disease
MONDO:0015140A progressive dementia with reduction of cognitive functions. It presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset, usually before 60 years old.
Also known as: EOFAD, early-onset familial autosomal dominant Alzheimer disease, early-onset, autosomal dominant Alzheimer disease
40 clinical trials for this condition and its sub-types, 31 tagged with Early-onset autosomal dominant Alzheimer disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Early-onset autosomal dominant Alzheimer disease
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Alzheimer disease 3 5 trials
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Alzheimer disease type 1 4 trials
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Alzheimer disease 4 3 trials
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Alzheimer disease 10 1 trial
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Alzheimer disease 11 1 trial
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Alzheimer disease 12 1 trial
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Alzheimer disease 13 1 trial
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Alzheimer disease 14 1 trial
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Alzheimer disease 5 1 trial
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Alzheimer disease 6 1 trial
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Alzheimer disease 7 1 trial
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Alzheimer disease 8 1 trial
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Could flickering lights and tones help fight Alzheimer's? major trial underway
Disease control CompletedThis study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …
Sponsor: Cognito Therapeutics, Inc. • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Gene therapy targets Alzheimer's in High-Risk group
Disease control CompletedThis early-stage trial tested a gene therapy called LX1001 in 15 people with Alzheimer's who have two copies of the APOE4 gene, a high-risk form. The therapy delivers a healthy APOE2 gene to try to change the course of the disease. The main goal was to check safety and side effec…
Phase 1/2 • Sponsor: Lexeo Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Simple blood test could spot Alzheimer's early
Diagnosis CompletedThis study is working on a blood test to help diagnose Alzheimer's disease. Researchers are measuring two specific markers in the blood of 200 people—some with Alzheimer's and some healthy—to see if these markers can reliably tell the difference. The goal is to create a simple, n…
Sponsor: Amoneta Diagnostics SAS • Aim: Diagnosis
Last updated Jun 27, 2026 08:05 UTC
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Light therapy shows promise for Alzheimer's prevention
Symptom relief CompletedThis study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…
Phase 2 • Sponsor: University of Florida • Aim: Symptom relief
Last updated Sep 21, 2026 19:00 UTC
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Acupuncture needles vs. sham: does it really help Alzheimer's?
Symptom relief CompletedThis study tested whether adding acupuncture to standard care can slow down memory and thinking problems in people with mild Alzheimer's disease. Researchers compared real acupuncture to a fake (sham) procedure in 160 participants to see if the effects were real or just a placebo…
Sponsor: Shanghai Institute of Acupuncture, Moxibustion and Meridian • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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DNA hunt for early Alzheimer's clues
Knowledge-focused CompletedThis study collected blood and DNA samples from 26 people with early-onset Alzheimer's disease and their close family members. Researchers analyzed the samples to find genetic changes and biomarkers that could help doctors diagnose, treat, and monitor the disease in the future. T…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Could changing your gut bacteria protect your memory?
Knowledge-focused CompletedThis study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…
Sponsor: George Washington University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Planning ahead: study tests if care wishes are honored
Knowledge-focused CompletedThis study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC