Distal biliary tract carcinoma

This phase II trial is testing whether alternating standard chemotherapy and immunotherapy with a targeted drug called pemigatinib can help people with advanced biliary tract cancers that have FGFR2 alterations. The study includes adults with cancer that cannot be removed by surg…

This study tests a surgery called total pancreatectomy with islet autotransplantation (TPIAT) in 30 adults with certain pancreatic tumors who are at high risk for a dangerous leak after standard surgery. The procedure removes the entire pancreas and transplants the insulin-making…

This study tests a new drug called ivonescimab against standard chemotherapy (FOLFOX) for people with advanced bile duct cancer that has worsened after initial treatment. About 72 participants who were in the SAFIR-ABC10 trial will be randomly assigned to receive either ivonescim…

This trial is investigating whether giving a combination of chemotherapy and immunotherapy before surgery, and continuing immunotherapy after, can improve outcomes for people with a rare and aggressive type of bile duct cancer. Participants will be randomly assigned to receive ei…

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas who are at high risk of complications. The main goal is to see if total removal helps patients live longer without hurting …

This trial compares two surgical techniques for removing tumors near the pancreas (non-pancreatic periampullary adenocarcinomas). One method uses a single small incision plus one extra port, while the other uses the conventional five-port approach. The study will enroll 232 adult…

This early-stage trial tests a technique called PIPAC, which turns chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. The goal is to see if this method is safe and reduces side effects for people with biliary tract cancer that has spre…

This study looks at two types of metal stents (partially covered vs. bare) used to open blocked bile ducts in people with incurable cancer. The goal is to see which stent keeps the duct open longer and causes fewer problems. Sixty adults who already have a drainage tube will be r…

This early-phase study tests a new cell therapy for people with advanced biliary tract cancer (bile duct or gallbladder cancer) that has not responded to standard treatments. The therapy uses the patient's own immune T cells, enhanced with a protein called CD160 to better target …

This phase 3 trial is testing whether giving a targeted therapy after initial standard chemotherapy can help people with advanced biliary cancer live longer without their disease getting worse. Participants must have a tumor with a specific genetic change and stable disease after…

This study compares two types of Whipple surgery for people with pancreatic or nearby cancers: the traditional open surgery and a newer keyhole (laparoscopic) approach. About 90 adults with resectable tumors will be randomly assigned to one of the two procedures. The goal is to s…

This study follows 150 adults with liver or bile duct cancer who are receiving standard treatments like surgery, ablation, or chemotherapy. Researchers will collect repeated blood samples before, during, and after treatment to analyze tumor DNA, immune cells, and proteins. The go…

This study looks at 100 people who have had a Whipple procedure (pancreaticoduodenectomy) for cancers of the pancreas or nearby areas. The goal is to find factors before, during, and after surgery that raise the risk of a pancreatic fistula—a leak of digestive fluid that can caus…

This study tests whether personalized nutrition plans can improve recovery after Whipple surgery for pancreatic, bile duct, or ampullary cancers. Twenty patients in Pakistan will receive tailored meals and supplements before and after surgery, and be followed for 6 months. Resear…