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Dilated cardiomyopathy
MONDO:0005021Cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. It may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. It is a cause of congestive heart failure.
Also known as: dilated cardiomyopathy, familial dilated cardiomyopathy, idiopathic dilation cardiomyopathy, primary dilated cardiomyopathy
137 clinical trials for this condition and its sub-types, 76 tagged with Dilated cardiomyopathy itself.
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Sub-types of Dilated cardiomyopathy
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Familial dilated cardiomyopathy 7 trials · 61 incl. sub-types
29 sub-types
- Leber hereditary optic neuropathy 18 trials Sub-types →
- Familial isolated dilated cardiomyopathy 0 trials · 11 incl. sub-types Sub-types →
- Barth syndrome 5 trials
- Kearns-Sayre syndrome 5 trials
- Autosomal recessive limb-girdle muscular dystrophy type 2E 5 trials
- Emery-Dreifuss muscular dystrophy 2 trials · 4 incl. sub-types Sub-types →
- Autosomal recessive limb-girdle muscular dystrophy type 2C 4 trials
- Symptomatic form of muscular dystrophy of Duchenne and Becker in female carriers 4 trials
- Autosomal recessive limb-girdle muscular dystrophy type 2D 3 trials
- Histiocytoid cardiomyopathy 3 trials Sub-types →
- Autosomal recessive limb-girdle muscular dystrophy type 2F 2 trials
- PGM1-congenital disorder of glycosylation 1 trial
- Autosomal recessive limb-girdle muscular dystrophy type 2M 1 trial
- Autosomal recessive limb-girdle muscular dystrophy type 2W 1 trial
- Early-onset myopathy with fatal cardiomyopathy 1 trial
- DK1-congenital disorder of glycosylation 0 trials
- Cardiomyopathy, dilated, 100 0 trials
- Cardiomyopathy, dilated, 1LL 0 trials
- Cardiomyopathy, dilated, 1MM 0 trials
- Cardiomyopathy, dilated, 1QQ 0 trials
- Cardiomyopathy, dilated, 2I 0 trials
- Cardiomyopathy, dilated, 2K 0 trials
- Cardiomyopathy, dilated, 2M 0 trials
- Cardiomyopathy, dilated, 2j 0 trials
- Cardiomyopathy, dilated, 2l 0 trials
- Cardiomyopathy, dilated, 3C 0 trials
- Dilated cardiomyopathy 1J 0 trials
- Hypertrophic cardiomyopathy 25 0 trials
- Myofibrillar myopathy 1 0 trials
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Non-familial dilated cardiomyopathy 3 trials · 11 incl. sub-types
2 sub-types
- Cirrhotic cardiomyopathy 4 trials
- Peripartum cardiomyopathy 4 trials
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Viral dilated cardiomyopathy 0 trials
Most studied deeper sub-types
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Could infusions of cell 'Packages' repair failing hearts?
Disease control OngoingThis trial investigates whether intravenous infusions of tiny particles (extracellular vesicles) from heart progenitor cells can safely improve heart function in people with severe dilated cardiomyopathy and heart failure. Participants receive three infusions and are monitored fo…
Phase 1 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New device aims to restore heart function in failing hearts
Disease control PausedThis study tests a device called AccuCinch that is placed around the heart to help it pump more effectively. It is for people with heart failure and a weakened heart muscle. The goal is to see if the device improves quality of life, exercise ability, and reduces serious heart eve…
Sponsor: Ancora Heart, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Could your own stem cells repair a failing heart?
Disease control OngoingThis phase 2 trial is testing whether a patient's own bone marrow stem cells can improve heart function and ease symptoms in people with dilated cardiomyopathy and heart failure. Twenty participants will have stem cells collected from their hip and then infused into their heart a…
Phase 2 • Sponsor: Barts & The London NHS Trust • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Heart rhythm showdown: ablation may beat drugs for ventricular tachycardia
Disease control OngoingThis trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…
Sponsor: Western Sydney Local Health District • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Can a gene registry unlock the secrets of childhood heart failure?
Knowledge-focused OngoingThis study gathers health information from children under 18 who have cardiomyopathy linked to mutations in the MYBPC3 gene. Researchers aim to map the disease's natural course, identify risk factors, and measure how it affects quality of life. By reviewing past and future medica…
Sponsor: Tenaya Therapeutics • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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Could your genes raise your risk of heart muscle inflammation?
Knowledge-focused OngoingThis study examines genetic test results from over 600 people who had acute myocarditis (heart muscle inflammation) confirmed by MRI. Researchers want to find out how common certain gene variants are in this group and whether they are linked to worse outcomes like heart failure o…
Sponsor: French Cardiology Society • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC
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New study tracks rare genetic heart condition to guide future treatments
Knowledge-focused OngoingThis study follows about 35 people with dilated cardiomyopathy caused by a BAG3 gene mutation, a condition that weakens the heart muscle. Over three years, researchers will monitor heart function, symptoms, and quality of life using tests like imaging and blood work. The goal is …
Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Heart clinic gene test could save families from sudden death
Knowledge-focused By invitation onlyThis study aims to make genetic testing for inherited heart muscle disease available directly in heart failure clinics, instead of requiring a separate referral to a genetics specialist that can take years. Researchers will train heart doctors to order a simple blood or saliva te…
Sponsor: Thomas Roston • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Heart MRI could spot hidden disease in families before symptoms appear
Knowledge-focused OngoingThis study uses advanced heart MRI scans to look for the earliest signs of dilated cardiomyopathy (a weakened heart muscle) in close relatives of people already diagnosed. Researchers will follow 650 family members over time to see how genetic factors relate to heart changes. The…
Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New heart study aims to cut unnecessary pacemaker implants by half
Knowledge-focused OngoingThis study tests whether using an ultrasound measure of heart muscle coordination (mechanical dyssynchrony) can better select heart failure patients for cardiac resynchronization therapy (CRT) than current guidelines. About 500 patients will receive a CRT device, but pacing will …
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Heart disease study aims to unlock genetic secrets of dilated cardiomyopathy
Knowledge-focused OngoingThis study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …
Sponsor: Imperial College London • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Scientists build heart cells in a dish to unravel genetic heart disease
Knowledge-focused By invitation onlyThis study collects blood or skin samples from 100 adults with inherited heart rhythm disorders (like Long QT Syndrome or Brugada Syndrome) and healthy volunteers. Researchers will turn these samples into stem cells and then into heart cells to study how these diseases work and t…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC