Differentiated thyroid carcinoma

Researchers test a new surgical approach for thyroid cancer that has invaded the windpipe. They replace the affected section with a preserved aortic graft supported by a silicone stent. The goal is to remove all cancer and improve survival. The trial includes patients whose cance…

This study tests whether giving more radioactive iodine can help people with differentiated thyroid cancer whose tumor marker (thyroglobulin) is high but whose scans show nothing. One hundred adults who have already had their thyroid removed and one round of radioactive iodine wi…

This phase II trial tests two drugs—anlotinib and benmelstobart—as a second-line treatment for people with advanced or metastatic differentiated thyroid cancer that has not responded to first-line therapy. The study will enroll 23 participants and measure how many see their tumor…

This study will enroll 40 people with high-risk differentiated thyroid cancer who need radioactive iodine therapy. After stopping their own thyroid hormones, participants will receive either standard levothyroxine alone or levothyroxine plus liothyronine. The goal is to see which…

This study compares two strategies for using levothyroxine to suppress TSH in patients with advanced thyroid cancer that cannot be fully removed. The standard approach keeps TSH very low (below 0.1), but this can cause side effects. The trial will test if a slightly higher TSH ta…

This study compares two types of surgery for people with early-stage thyroid cancer located in the isthmus (the middle part of the thyroid). One group will have a smaller surgery called extended isthmusectomy, which removes only the tumor and nearby lymph nodes. The other group w…

This early-stage trial tests an experimental drug called ACC-1898, taken as a daily pill, in adults with advanced solid tumors (like liver, kidney, or stomach cancer) that have not responded to standard treatments. The main goals are to find a safe dose and see how the body handl…

This phase 3 trial tests whether combining desiccated thyroid extract (DTE) with standard levothyroxine can help intermediate-to-high risk thyroid cancer patients reach their TSH suppression targets faster and more safely after surgery. Many patients on levothyroxine alone strugg…

This pilot trial tests whether adding emotional support to a cancer information website helps young adults (ages 20-39) with thyroid, melanoma, or testicular cancer feel less worried and distressed. 142 participants will either get general cancer info or the same info plus person…

Low-risk thyroid cancer grows very slowly and has a 99% survival rate, but choosing among three treatment options can be stressful. This study gives patients a decision aid pamphlet right after diagnosis, before they see a surgeon. The pamphlet explains the options and lists ques…

After thyroid surgery for differentiated thyroid cancer, patients often need to take thyroid hormone at doses that keep TSH in a specific target range. Researchers at West China Hospital are testing whether adding a short educational video to standard instructions helps patients …

This study looks at how patients with radioiodine-refractory differentiated thyroid cancer are treated in the real world after first-line therapy stops working. It will compare two approaches: a targeted combination (dabrafenib plus trametinib) guided by a specific gene mutation,…