Diastolic heart failure

This study tests a multidisciplinary clinic that provides heart failure patients with educational videos, a self-management kit, and follow-up phone calls after hospital discharge. The goal is to reduce 30-day readmission rates and improve patient satisfaction. The trial enrolls …

This trial tests whether intravenous (IV) iron or oral iron pills work better for adults with congestive heart failure who also have low iron levels. Participants are randomly assigned to receive either a one-time IV infusion of ferric carboxymaltose (with a possible repeat dose)…

This pilot study compared a heart ablation procedure (pulmonary vein isolation) to standard medications for managing atrial fibrillation in people with heart failure with preserved ejection fraction. Only 13 participants were enrolled before the study was terminated early. The ma…

This study tested an investigational drug called LY3540378 in 332 adults with worsening chronic heart failure where the heart pumps normally but doesn't fill properly (HFpEF). The goal was to see if the drug could improve heart function and safety compared to a placebo. The trial…

This small study tested a drug called PL-3994 in 15 people with a type of heart failure where the heart pumps normally but doesn't relax properly. The goal was to see if the drug improved heart function and if effects differed between men and women. The trial was terminated early…

This was a very early (Phase 1) study testing a drug called HS135 in obese patients who have both pulmonary hypertension and a type of heart failure called HFpEF. The trial was terminated after enrolling only 4 people, so we have no useful information on whether HS135 is safe or …

This study tested a program called HEART Camp Connect, which uses a virtual coach to help adults with heart failure exercise 150 minutes per week. Only 11 people enrolled before the trial was stopped. Researchers wanted to see if the program improved exercise habits and heart-rel…

This study tested whether a special breathing exercise program could help people with systolic heart failure walk farther and feel better. The trial planned to enroll 65 adults with moderate heart failure, but it was terminated early. Participants would have been assigned to eith…

This study looked at how applying positive or negative pressure around the body affects exercise in people with heart failure with preserved ejection fraction. 27 participants, including healthy volunteers and heart failure patients, were tested non-invasively and some invasively…

This study aims to find out how common transthyretin amyloidosis cardiomyopathy (ATTR-CM) is in Russian patients with a certain type of heart failure. Researchers will review medical records and then invite some patients for extra heart tests to confirm or rule out ATTR-CM. The g…