Diabetic ketoacidosis

This study compares two types of IV fluids—saline and Ringer lactate—in 300 adults with severe diabetic ketoacidosis (DKA) admitted to the ICU. The goal is to see which fluid helps resolve DKA faster within 24 hours. Current guidelines recommend saline, but it may cause side effe…

This study tests whether automated insulin pumps (hybrid closed loop systems) can help underserved adults with type 1 diabetes better control their blood sugar. About 140 participants will be randomly assigned to use one of three FDA-approved pump systems or continue with standar…

This study tests whether a single infusion of arginine hydrochloride, a natural amino acid, can help people with type 2 diabetes recover faster from diabetic ketoacidosis (DKA), a serious complication. Sixty adults arriving at emergency rooms with DKA will receive either arginine…

This study tests whether a balanced electrolyte solution (Plasma-Lyte 148) helps people with moderate to severe diabetic ketoacidosis recover faster than standard saline. About 680 critically ill adults in the emergency department will be randomly assigned to one of the two fluid…

Researchers at Ankara Etlik City Hospital are studying whether the perfusion index, a blood-flow reading taken with a standard pulse oximeter, can predict the severity of diabetic ketoacidosis in adults arriving at the emergency department. The study will follow 140 patients aged…

This study looks at how blood sugar changes day-to-day in people with ketosis-prone diabetes as they go into remission. Researchers will use this data to build a math model that describes the remission process. The study involves 12 African American adults with a BMI of 28 or hig…

This study looks at children aged 2-16 who are newly diagnosed with type 1 diabetes. It checks if those who also have diabetic ketoacidosis (a serious complication) show early signs of kidney or heart injury using special blood and urine tests. The goal is to better understand wh…

This study is testing whether it's practical to screen thousands of children for type 1 diabetes and celiac disease during their regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 and follow them for about 5 years. The goal is to see if paren…

This study examines patients in intensive care who have overdosed on metformin, a common diabetes drug. Researchers will compare those who took only metformin with those who also took dapagliflozin, another diabetes medication. The goal is to find specific signs that could help d…