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Desmoid tumor
MONDO:0007608A desmoid tumor (DT) is a benign, locally invasive soft tissue tumor associated with a high recurrence rate but with no metastatic potential.
Also known as: aggressive fibromatosis, deep fibromatosis, deep fibromatosis/desmoid tumor, deep fibromatosis/desmoid tumour, desmoid fibromatosis, desmoid tumor, desmoid type fibromatosis, desmoid-type fibromatosis
1471 clinical trials for this condition and its sub-types, 36 tagged with Desmoid tumor itself.
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Sub-types of Desmoid tumor
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New pill shows promise for rare tumor in japanese patients
Disease control OngoingThis phase 2 study tests the drug nirogacestat in 20 Japanese adults with desmoid tumors that are growing. The goal is to see if the drug can shrink tumors or stop them from getting worse. Participants take nirogacestat as an oral tablet, and researchers will monitor tumor respon…
Phase 2 • Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Promising drug may shrink rare tumors in kids without surgery
Disease control OngoingThis study tests a drug called nirogacestat in children and teens with desmoid tumors that have grown despite treatment and cannot be surgically removed. The goal is to see if the drug can stop or slow tumor growth and to check for side effects. About 31 participants aged 1 to 18…
Phase 2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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Immunotherapy duo takes on rare tumors
Disease control OngoingThis phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New hope for rare tumor patients: AL102 drug trial launches
Disease control OngoingThis study tests a drug called AL102 (varegacestat) in people with desmoid tumors that are growing. Desmoid tumors are non-cancerous but can be painful and invasive. The trial has two parts: Part A checks safety and tumor changes, and Part B compares AL102 to a placebo to see if …
Phase 2/3 • Sponsor: Immunome, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New pill shows promise for Hard-to-Treat cancers in early trial
Disease control OngoingThis early-phase study tests a new oral drug called E7386 in about 60 adults with advanced solid tumors (like desmoid tumors) that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. Researchers will also watch for any tu…
Phase 1 • Sponsor: Eisai Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Electric pulses plus chemo aimed at rare tumor, but study pulled
Disease control CancelledThis study planned to test electrochemotherapy (ECT) with bleomycin in people with desmoid fibromatosis, a non-cancerous but locally aggressive tumor. The goal was to see if the treatment could shrink the tumor and improve symptoms like pain. However, the study was withdrawn befo…
Sponsor: Istituto Ortopedico Rizzoli • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New drug E7386 tested for tough cancers
Disease control OngoingThis early-phase study tests a new drug called E7386 in about 70 people with advanced solid tumors, including colorectal cancer. The main goal is to check safety and find the right dose. Participants have tumors that no longer respond to standard treatments.
Phase 1 • Sponsor: Eisai Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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Can a targeted procedure ease the burden of desmoid tumors?
Symptom relief By invitation onlyThis study asks whether a procedure called percutaneous ablation can reduce symptoms and improve daily life for adults with desmoid tumors. Participants will complete surveys before and after the procedure to track symptom severity, pain, recovery, and how the tumor responds on i…
Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Aug 12, 2026 00:00 UTC
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French launch largest study of rare tumor disease
Knowledge-focused OngoingThis study aims to create the largest French database of people diagnosed with aggressive fibromatosis, a rare tumor that grows in connective tissue. Researchers will collect tissue samples, medical history, and genetic information from 628 participants across France. The goal is…
Sponsor: Centre Oscar Lambret • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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New national registry aims to improve care for rare genetic polyposis syndromes
Knowledge-focused OngoingThis study is a national registry collecting data from 1500 people with familial adenomatous polyposis (FAP) and related conditions across 28 Italian centers. It aims to better understand how these diseases progress, how they are currently managed, and what factors influence outc…
Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC