Cushing syndrome
MONDO:0018912Cushing's syndrome (CS) encompasses a group of hormonal disorders caused by prolonged and high exposure levels to glucocorticoids that can be of either endogenous (adrenal cortex production) or exogenous (iatrogenic) origin.
Also known as: hypercortisolism, Cushing syndrome, Cushing's syndrome, cortisol Excess, hyperadrenocorticism, pituitary basophilism, suprarenogenic syndrome, adrenal hyperfunction resulting from pituitary ACTH excess
66 clinical trials for this condition and its sub-types, 42 tagged with Cushing syndrome itself.
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Sub-types of Cushing syndrome
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Endogenous Cushing syndrome 3 trials · 38 incl. sub-types
2 sub-types
- ACTH-dependent Cushing syndrome 23 trials · 26 incl. sub-types Sub-types →
- ACTH-independent Cushing syndrome 9 trials · 11 incl. sub-types Sub-types →
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Exogenous Cushing syndrome 1 trial
Most studied deeper sub-types
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Can a stronger radiation dose fix hormone overload?
Disease control Not yet recruitingResearchers are testing whether a higher dose of proton beam therapy can normalise hormone levels better than standard radiotherapy in people with functioning pituitary tumours, including acromegaly and Cushing's disease. Participants receive about six weeks of either standard-do…
Phase 3 • Sponsor: University College, London • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Could a drug tame excess cortisol in a common hormone disorder?
Disease control Not yet recruitingThis study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New hope for Cushing's patients with high blood pressure
Disease control Not yet recruitingThis study tests a drug called osilodrostat in 63 adults with Cushing's syndrome and high blood pressure. The goal is to see if it can safely lower blood pressure by reducing cortisol levels. Participants will take the drug or a placebo for 30 weeks, with doses adjusted based on …
Phase 4 • Sponsor: RECORDATI GROUP • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New scan could spot invisible brain tumors
Diagnosis Not yet recruitingThis study tests whether a special PET scan (18FET) can find small pituitary tumors that standard MRI scans miss. About 30 adults with suspected hormone-secreting pituitary tumors will receive the scan. If it works, it could help doctors decide on surgery or radiation without nee…
Phase 2 • Sponsor: University Hospital, Lille • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC