Cushing syndrome
MONDO:0018912Cushing's syndrome (CS) encompasses a group of hormonal disorders caused by prolonged and high exposure levels to glucocorticoids that can be of either endogenous (adrenal cortex production) or exogenous (iatrogenic) origin.
Also known as: hypercortisolism, Cushing syndrome, Cushing's syndrome, cortisol Excess, hyperadrenocorticism, pituitary basophilism, suprarenogenic syndrome, adrenal hyperfunction resulting from pituitary ACTH excess
66 clinical trials for this condition and its sub-types, 42 tagged with Cushing syndrome itself.
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Sub-types of Cushing syndrome
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Endogenous Cushing syndrome 3 trials · 38 incl. sub-types
2 sub-types
- ACTH-dependent Cushing syndrome 23 trials · 26 incl. sub-types Sub-types →
- ACTH-independent Cushing syndrome 9 trials · 11 incl. sub-types Sub-types →
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Exogenous Cushing syndrome 1 trial
Most studied deeper sub-types
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Could a drug tame excess cortisol in a common hormone disorder?
Disease control Not yet recruitingThis study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New hope for Cushing's patients with high blood pressure
Disease control Not yet recruitingThis study tests a drug called osilodrostat in 63 adults with Cushing's syndrome and high blood pressure. The goal is to see if it can safely lower blood pressure by reducing cortisol levels. Participants will take the drug or a placebo for 30 weeks, with doses adjusted based on …
Phase 4 • Sponsor: RECORDATI GROUP • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC