Craniopharyngioma

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This study tests a drug called tocilizumab, already used for arthritis, in children and young adults with a rare brain tumor called adamantinomatous craniopharyngioma that has come back or is growing. The goal is to see if the drug can shrink the tumor or stop it from growing. Ab…

This study is testing a drug called Tovorafenib for children and young adults with craniopharyngioma, a rare, non-cancerous brain tumor that can cause serious health problems. The drug is taken by mouth and works by blocking a protein that helps the tumor grow. The trial aims to …

This study tests an oral drug called MEKTOVI (binimetinib) in children and young adults with a rare brain tumor called adamantinomatous craniopharyngioma. The goal is to see if the drug can shrink or control the tumor in patients whose tumor has come back after treatment. About 3…

This study tests the safety and effectiveness of anlotinib, a drug that blocks blood vessel growth, in 57 adults whose craniopharyngioma has come back after surgery. The main goal is to see if the drug shrinks the tumor. Researchers will also track how long the tumor stays contro…

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor r…

This study is testing a new radioactive tracer called 68Ga-MY6349 to see if it can help diagnose craniopharyngioma, a rare brain tumor, using PET/CT scans. The tracer targets a protein called Trop-2, which is often found on these tumors. Twenty participants with suspected or conf…

This trial tests a new anti-fog suction device that keeps the camera lens clear during nose-to-pituitary tumor surgery. Twenty adults with pituitary or craniopharyngioma tumors will either get the device or the usual water-squirt method. The goal is to see if the device reduces f…

This Phase 3 trial tests whether metformin, a widely used diabetes drug, can improve memory and thinking in children and teens who have finished treatment for a brain tumor. About 140 participants aged 7 to 21 will take metformin or a placebo for 16 weeks. Researchers will measur…

This study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI technique…

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …