Coronary atherosclerosis

This trial tests a medical device that has not been approved or cleared by the U.S. FDA. Researchers want to learn whether the device is safe and whether it can help people with a specific condition. Participants receive the device as part of the study, and the team monitors thei…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This study tests a new device called the Shockwave C2 Aero, which uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 200 people with coronary artery disease will be enrolled across 8 U.S. sites. The goal is to see if the device works saf…

This study compares two methods to prepare severely calcified heart arteries before placing a stent: a shockwave device that breaks up calcium versus standard balloon treatment. It also tests whether using a special camera inside the artery or standard X-ray leads to better resul…

This study tests a special balloon that uses shockwaves to break up hardened calcium deposits in heart arteries. About 200 people with severe blockages will receive this treatment to see if it safely improves blood flow and reduces the risk of heart attack or death. The goal is t…

This pilot study tests whether taking a synbiotic supplement (a mix of probiotics and prebiotics) for 10 weeks can lower TMAO levels and improve other heart health markers in 80 adults who recently had a heart attack. The goal is to see if changing gut bacteria can help prevent f…

This study compares two methods to treat severely calcified coronary arteries: one uses a special balloon that inflates at very high pressure, and the other combines a rotating burr with sound waves to break up calcium. Researchers will enroll 162 adults with hardened arteries to…

Researchers are testing whether an open-source artificial intelligence model can measure coronary artery calcium on routine chest CT scans that were not originally taken for heart imaging. The study uses existing scans from about 1,950 people at a German hospital, including patie…

This study looks at whether the urate crystals that cause gout flare-ups in the feet are linked to plaque buildup in the heart's arteries. Researchers will use two types of CT scans to measure urate deposits in the feet and plaque in the coronary arteries of 200 adults with gout …

This observational study will follow 3000 patients with severely calcified coronary arteries who undergo a procedure to open the blockages (PCI). Researchers will track outcomes like heart attacks and repeat procedures over time. The goal is to learn which techniques work best in…

This study will use AI-guided CT scans to look for signs of heart disease in 100 former high-intensity athletes, like NFL alumni or Division I players, aged 30 and older. The goal is to find out how common coronary artery disease is in this group and understand the types of plaqu…

This study is looking at a specific type of hard plaque in heart arteries called a calcified nodule, which can cause sudden heart attacks and is hard to treat. Researchers will use special cameras inside the arteries to see these plaques in detail and track how patients do over t…