Connective tissue disorder
MONDO:0003900A disease involving the connective tissue.
Also known as: connective tissue disease, connective tissue disease or disorder, connective tissue diseases, connective tissue disorder, connective tissue disorders, disease of connective tissue, disease or disorder of connective tissue, disease, connective tissue
4637 clinical trials for this condition and its sub-types, 70 tagged with Connective tissue disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Connective tissue disorder
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Connective tissue neoplasm 1 trial · 2,404 incl. sub-types
13 sub-types
- Bone neoplasm 26 trials · 2,116 incl. sub-types Sub-types →
- Fibroblastic neoplasm 0 trials · 210 incl. sub-types Sub-types →
- Tumor of adipose tissue 1 trial · 98 incl. sub-types Sub-types →
- Chondrosarcoma 39 trials · 44 incl. sub-types Sub-types →
- Tenosynovial giant cell tumor 12 trials · 16 incl. sub-types Sub-types →
- Chondroma 4 trials Sub-types →
- Cholangiolocellular carcinoma 1 trial
- Solitary fibrous tumor/hemangiopericytoma 1 trial
- Angiomyxoma 0 trials
- Cartilage cancer 0 trials
- Dartoic leiomyoma 0 trials
- Lipofibromatosis-like neural tumor 0 trials
- Scirrhous adenocarcinoma 0 trials
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Rheumatic disorder 90 trials · 1,792 incl. sub-types
30 sub-types
- Rheumatoid arthritis 576 trials · 795 incl. sub-types Sub-types →
- Lupus erythematosus 39 trials · 548 incl. sub-types Sub-types →
- Scleroderma 47 trials · 305 incl. sub-types Sub-types →
- Autoinflammatory syndrome 21 trials · 207 incl. sub-types Sub-types →
- Juvenile idiopathic arthritis 107 trials · 115 incl. sub-types Sub-types →
- Dermatomyositis 81 trials · 100 incl. sub-types Sub-types →
- Polymyalgia rheumatica 30 trials
- Rheumatic fever 16 trials
- Mixed connective tissue disease 15 trials
- Reactive arthritis 6 trials
- Camptodactyly-arthropathy-coxa vara-pericarditis syndrome 4 trials
- Gorham-Stout disease 2 trials
- Sweet syndrome 2 trials
- Palindromic rheumatism 1 trial
- Rheumatic disease of mitral valve 1 trial
- IL10-related early-onset inflammatory bowel disease 0 trials Sub-types →
- LAMA5-related multisystemic syndrome 0 trials
- Reye syndrome 0 trials
- Wissler syndrome 0 trials
- Acroosteolysis dominant type 0 trials
- Chondrocalcinosis 2 0 trials
- Fibroblastic rheumatism 0 trials
- Idiopathic juvenile osteoporosis 0 trials
- Intermittent hydrarthrosis 0 trials
- Interstitial granulomatous dermatitis with arthritis 0 trials
- Isolated sternocostoclavicular hyperostosis 0 trials
- Myalgia-eosinophilia syndrome associated with tryptophan 0 trials
- Progeria-associated arthropathy 0 trials
- Rheumatic pulmonary valve disease 0 trials
- Unexplained long-lasting fever/inflammatory syndrome 0 trials
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Hereditary disorder of connective tissue 0 trials · 1,311 incl. sub-types
88 sub-types
- Systemic lupus erythematosus 516 trials · 522 incl. sub-types Sub-types →
- Chronic myelogenous leukemia, BCR-ABL1 positive 211 trials · 253 incl. sub-types Sub-types →
- Uterine corpus leiomyoma 104 trials · 109 incl. sub-types Sub-types →
- Acquired polycythemia vera 90 trials
- Chondrosarcoma 39 trials · 44 incl. sub-types Sub-types →
- Type 2 collagenopathy 0 trials · 39 incl. sub-types Sub-types →
- CHILD syndrome 37 trials
- Desmoid tumor 36 trials Sub-types →
- Familial isolated pituitary adenoma 1 trial · 31 incl. sub-types Sub-types →
- Inherited acute myeloid leukemia 1 trial · 25 incl. sub-types Sub-types →
- Hereditary periodic fever syndrome 5 trials · 24 incl. sub-types Sub-types →
- Marfan and Marfan-related disorder 1 trial · 22 incl. sub-types Sub-types →
- VEXAS syndrome 18 trials
- Hypermobility spectrum disorder 16 trials
- Peyronie disease 12 trials
- Aicardi-Goutieres syndrome 9 trials Sub-types →
- Autosomal recessive inherited pseudoxanthoma elasticum 7 trials
- Ewing sarcoma of bone 5 trials
- TREX1-related type 1 interferonopathy 0 trials · 5 incl. sub-types Sub-types →
- Camptodactyly-arthropathy-coxa vara-pericarditis syndrome 4 trials
- Chronic recurrent multifocal osteomyelitis 3 trials · 4 incl. sub-types Sub-types →
- Blau syndrome 3 trials
- Ollier disease 3 trials
- Autoimmune interstitial lung disease-arthritis syndrome 3 trials Sub-types →
- Deficiency of adenosine deaminase 2 3 trials
- Hereditary multiple osteochondromas 3 trials Sub-types →
- Inherited torticollis 3 trials
- Maffucci syndrome 2 trials
- STING-associated vasculopathy with onset in infancy 2 trials
- Familial chilblain lupus 2 trials Sub-types →
- Proteosome-associated autoinflammatory syndrome 2 trials Sub-types →
- Sweet syndrome 2 trials
- ADAR-related type 1 interferonopathy 0 trials · 1 incl. sub-types Sub-types →
- Singleton-Merten dysplasia 1 trial Sub-types →
- Arterial tortuosity syndrome 1 trial
- Cherubism 1 trial Sub-types →
- Hyperparathyroidism 2 with jaw tumors 1 trial
- Infantile myofibromatosis 1 trial Sub-types →
- Neonatal severe primary hyperparathyroidism 1 trial
- Ossification of the posterior longitudinal ligament of the spine 1 trial
- EMILIN-1-related connective tissue disease 0 trials
- Ehlers-Danlos syndrome, kyphoscoliotic type 1 0 trials
- IFIH1-related type 1 interferonopathy 0 trials Sub-types →
- IL10-related early-onset inflammatory bowel disease 0 trials Sub-types →
- LAMA5-related multisystemic syndrome 0 trials
- MASS syndrome 0 trials
- Pelger-Huet-like anomaly and episodic fever with abdominal pain 0 trials
- RNASEH2A-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2B-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2C-related type 1 interferonopathy 0 trials Sub-types →
- RNU7-1-related type 1 interferonopathy 0 trials Sub-types →
- SAMHD1-related type 1 interferonopathy 0 trials Sub-types →
- Sharpin-related autoinflammatory syndrome 0 trials
- Spondyloenchondrodysplasia with immune dysregulation 0 trials
- X-linked reticulate pigmentary disorder 0 trials
- Acroosteolysis dominant type 0 trials
- Aneurysmal bone cyst 0 trials
- Arterial tortuosity-bone fragility syndrome 0 trials
- Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation 0 trials
- Autoinflammatory disease, X-linked 0 trials
- Autoinflammatory disease, multisystem, with immune dysregulation, X-linked 0 trials Sub-types →
- Autoinflammatory disease, systemic, with vasculitis 0 trials
- Autoinflammatory syndrome with immunodeficiency 0 trials
- Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis 0 trials
- Autoinflammatory syndrome, familial, Behcet-like 0 trials Sub-types →
- Bone fragility with contractures, arterial rupture, and deafness 0 trials
- Brittle cornea syndrome 0 trials Sub-types →
- Chondrocalcinosis 2 0 trials
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome 0 trials
- Diaphyseal medullary stenosis-bone malignancy syndrome 0 trials
- Encephalocraniocutaneous lipomatosis 0 trials
- Familial ossifying fibroma 0 trials
- Hyperparathyroidism 1 0 trials
- Hyperparathyroidism 3 0 trials
- Hyperparathyroidism 4 0 trials
- Idiopathic juvenile osteoporosis 0 trials
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Juvenile hyaline fibromatosis 0 trials
- Linkeropathy 0 trials Sub-types →
- Multiple epiphyseal dysplasia due to collagen 9 anomaly 0 trials Sub-types →
- Multiple symmetric lipomatosis 0 trials Sub-types →
- Neonatal inflammatory skin and bowel disease 0 trials Sub-types →
- Progeroid and marfanoid aspect-lipodystrophy syndrome 0 trials
- Pseudo-TORCH syndrome 2 0 trials
- Psoriasis 14, pustular 0 trials
- Pyogenic arthritis-pyoderma gangrenosum-acne syndrome 0 trials
- Thrombocytopenia 6 0 trials
- Trichohepatoenteric syndrome 0 trials Sub-types →
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Disease of the tendon 126 trials · 192 incl. sub-types
3 sub-types
- Tendinitis 24 trials · 77 incl. sub-types Sub-types →
- Tendon sheath disorder 0 trials · 30 incl. sub-types Sub-types →
- Tendinosis 17 trials
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Benign connective and soft tissue neoplasm 0 trials · 101 incl. sub-types
5 sub-types
- Bone benign neoplasm 1 trial · 70 incl. sub-types Sub-types →
- Benign soft tissue neoplasm 0 trials · 16 incl. sub-types Sub-types →
- Benign lipomatous neoplasm 0 trials · 15 incl. sub-types Sub-types →
- Benign osteogenic neoplasm 0 trials Sub-types →
- Lipofibromatosis 0 trials
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Fasciitis 7 trials · 97 incl. sub-types
6 sub-types
- Plantar fasciitis 85 trials
- Necrotizing fasciitis 7 trials
- Eosinophilic fasciitis 1 trial
- Ischemic fasciitis 0 trials
- Nodular fasciitis 0 trials Sub-types →
- Proliferative fasciitis 0 trials
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Collagenopathy 3 trials · 42 incl. sub-types
3 sub-types
- Type 2 collagenopathy 0 trials · 39 incl. sub-types Sub-types →
- Disseminated eosinophilic collagen disease 0 trials
- Multiple epiphyseal dysplasia due to collagen 9 anomaly 0 trials Sub-types →
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Interstitial cystitis 39 trials
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Periostitis 0 trials · 16 incl. sub-types
2 sub-types
- Alveolar periostitis 16 trials
- Orbital periostitis 0 trials
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Synovitis 15 trials
1 sub-type
- Gonococcal synovitis 0 trials
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Overlapping connective tissue disease 2 trials · 15 incl. sub-types
2 sub-types
- Mixed connective tissue disease 15 trials
- MASS syndrome 0 trials
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Panniculitis 3 trials · 6 incl. sub-types
6 sub-types
- Lipodermatosclerosis 1 trial
- Nodular non-suppurative panniculitis 1 trial
- Panniculitis and localized lipodystrophy 1 trial
- Cytophagic histiocytic panniculitis 0 trials
- Erythema nodosum 0 trials
- Lupus erythematosus panniculitis 0 trials
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Enthesopathy 2 trials · 4 incl. sub-types
5 sub-types
- Enthesitis 2 trials
- Fibular collateral ligament bursitis 0 trials
- Olecranon bursitis 0 trials
- Pes anserinus tendinitis or bursitis 0 trials
- Tibial collateral ligament bursitis 0 trials
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Ochronosis disorder 1 trial
1 sub-type
- Exogenous ochronosis 0 trials
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Ainhum 0 trials
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Interstitial keratitis 0 trials
1 sub-type
- Diffuse interstitial keratitis 0 trials
Most studied deeper sub-types
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New pill could tame lupus flares in major trial
Disease control OngoingThis phase 3 trial tests whether adding cenerimod, a daily pill, to standard lupus treatments can reduce symptoms in adults with moderate-to-severe systemic lupus erythematosus (SLE). About 470 participants will receive either cenerimod or a placebo for 12 months. Researchers wil…
Phase 3 • Sponsor: Viatris Innovation GmbH • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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New lupus pill shows promise in major trial
Disease control OngoingThis Phase 3 study tests whether adding cenerimod to standard lupus treatments can better control moderate-to-severe lupus symptoms. About 451 adults will receive either cenerimod or a placebo for 12 months. The main goal is to see if more people improve on a lupus disease activi…
Phase 3 • Sponsor: Viatris Innovation GmbH • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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New lupus drug tested for Long-Term safety in 680 patients
Disease control By invitation onlyThis study looks at the long-term safety of cenerimod in adults with moderate-to-severe lupus. About 680 participants who were in a previous study will take cenerimod for up to 3 years, along with their usual lupus medications. Researchers will track side effects and see how well…
Phase 3 • Sponsor: Viatris Innovation GmbH • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New lupus drug shows promise in Long-Term safety trial
Disease control By invitation onlyThis study looks at the long-term safety of a drug called litifilimab for people with active lupus. About 864 adults who finished earlier studies will continue taking the drug for up to 3 years, along with their usual treatments. The goal is to see how safe it is and how well it …
Phase 3 • Sponsor: Biogen • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New drug hope for scleroderma patients with lung complications
Disease control OngoingThis study tests an experimental drug called ifetroban in 34 adults with a severe form of scleroderma (diffuse cutaneous systemic sclerosis) or scleroderma-related lung disease (pulmonary arterial hypertension). The main goal is to see if the drug is safe and whether it can impro…
Phase 2 • Sponsor: Cumberland Pharmaceuticals • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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New lupus drug afimetoran enters Mid-Stage trial
Disease control OngoingThis phase 2 trial tests whether the drug afimetoran can safely control active systemic lupus erythematosus (SLE) better than a placebo. About 268 participants with lupus will receive either afimetoran or a placebo for 48 weeks, with an extension period allowing placebo users to …
Phase 2 • Sponsor: Beeline Medicines Corporation • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New lupus pill shows promise in Mid-Stage trial
Disease control OngoingThis Phase 2 study tests an experimental oral drug called ESK-001 in 408 adults with active systemic lupus erythematosus (SLE). Participants receive either ESK-001 or a placebo for 48 weeks to see if the drug can reduce disease activity. The goal is to find a new treatment option…
Phase 2 • Sponsor: Alumis Inc • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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CAR-T therapy for autoimmune diseases: study withdrawn before starting
Disease control CancelledThis study planned to test a new cell therapy (CD19-BCMA CAR-T) for people with connective tissue diseases like lupus and rheumatoid arthritis. The goal was to see if it is safe and can control the disease. However, the study was withdrawn before enrolling any participants, so no…
Sponsor: Guangzhou Bio-gene Technology Co., Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:39 UTC
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Which treatment works best for Dupuytren's? major trial aims to find out
Disease control OngoingThis study compares three treatments for Dupuytren's contracture, a hand condition that causes fingers to bend inward. The treatments are needle fasciotomy (a quick in-office procedure), collagenase injection (a drug that breaks up the tight cord), and surgery (limited fasciectom…
Phase 4 • Sponsor: Tampere University • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New hope for lung scarring: phase 3 trial underway
Disease control OngoingThis study tests an experimental drug, BMS-986278, in about 1057 adults with progressive pulmonary fibrosis, a condition where lung scarring worsens over time. Participants receive either the drug or a placebo to see if it can slow lung function decline and is safe. The trial is …
Phase 3 • Sponsor: Bristol-Myers Squibb • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New hope for PAH patients: Long-Term drug safety trial opens
Disease control By invitation onlyThis study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug remains s…
Phase 3 • Sponsor: United Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New lupus pill shows promise in major trial
Disease control OngoingThis study tests whether the drug deucravacitinib can safely control symptoms in people with active moderate-to-severe lupus. About 513 participants will receive either the drug or a placebo. The goal is to see if the drug reduces lupus disease activity better than placebo.
Phase 3 • Sponsor: Bristol-Myers Squibb • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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New pill could tame lupus flares
Disease control OngoingThis Phase 3 trial tests whether the oral drug deucravacitinib can safely control moderate to severe lupus better than a placebo. About 516 adults with active lupus are taking either the drug or a dummy pill for several months. The goal is to see if the drug reduces lupus symptom…
Phase 3 • Sponsor: Bristol-Myers Squibb • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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New gum graft material tested for better healing
Disease control OngoingThis study tests two types of donated human tissue grafts for treating gum recession. Twenty adults who need a gum graft will receive either a standard graft or a new micro-surfaced version. Researchers will compare how well the gum covers the tooth root, how the site heals, and …
Phase 4 • Sponsor: Ohio State University • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Can AI fake a cell image well enough to fool a lab expert?
Diagnosis OngoingResearchers want to know whether computer-generated images of ANA Hep-2 cells look real enough to pass as genuine microscope pictures. They ask 300 experienced lab professionals from multiple medical centers to judge a mix of real and AI-made images and to identify the cell patte…
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine • Aim: Diagnosis
Last updated Sep 12, 2026 00:00 UTC
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Can an online course keep arthritis patients working?
Symptom relief OngoingThis study tests an online program designed to help people with inflammatory arthritis remain employed. The program includes eLearning modules, group video sessions, and consultations with an occupational therapist and vocational counselor. About 528 participants from three Canad…
Sponsor: University of British Columbia • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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New injection aims to soothe painful fat lumps
Symptom relief OngoingThis phase 2 trial tests whether CBL-514 injections can reduce pain from lipomas in people with Dercum's disease. Nineteen adults with at least 4 painful lipomas will receive either the drug or a placebo. The main goal is to see if the treatment lowers pain scores.
Phase 2 • Sponsor: Caliway Biopharmaceuticals Co., Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC