Congenital syphilis

MONDO:0005714

A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.

Also known as: MTCT of syphilis, congenital syphilis, mother-to-child transmission of syphilis

16 clinical trials for this condition and its sub-types, 7 tagged with Congenital syphilis itself.

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Where it sits in the disease tree

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Part of

↑ Syphilis (56) ↑ Infectious embryofetopathy (25)

Sub-types of Congenital syphilis

Early congenital syphilis 0 trials
Late congenital syphilis 0 trials

Including sub-types (16) Tagged with Congenital syphilis (7)

Trials to join now! 3 Not yet recruiting 3 Completed 1

Rapid dual test for HIV and syphilis could save newborns in guatemala

Diagnosis Completed

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

Sponsor: The University of Texas Health Science Center, Houston • Aim: Diagnosis

Last updated Aug 30, 2026 00:00 UTC

Congenital syphilis

Where it sits in the disease tree

Rapid dual test for HIV and syphilis could save newborns in guatemala