Congenital portosystemic shunt
MONDO:0018811Congenital portosystemic shunt is a rare, congenital anomaly of the great veins characterized by an abnormal communication between one or more veins of the portal and the caval systems, resulting in complete or partial diversion of the portal blood away from the liver to the systemic circulation. Clinical manifestations include liver atrophy, hypergalactosemia without uridine diphosphate enzyme deficiency, hyperammonemia, encephalopathy (resulting in learning disabilities, extreme fatigability and seizures), pulmonary hypertension, hypoxemia from hepatopulmonary syndrome and benign or malignant tumors.
Also known as: congenital portosystemic venous fistula
4 clinical trials for this condition and its sub-types, 4 tagged with Congenital portosystemic shunt itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Congenital portosystemic shunt
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Patent ductus venosus 0 trials
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New procedure aims to stop Liver-Related confusion by blocking rogue blood vessels
Disease control Not yet recruitingThis study tests a new procedure that uses an endoscope (a thin tube with a camera) to guide coils and glue into abnormal blood vessels in the liver. The goal is to block these vessels and reduce severe confusion (hepatic encephalopathy) in people with liver cirrhosis. The trial …
Sponsor: Rutgers, The State University of New Jersey • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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New study aims to unravel mysterious Lung-Liver connection
Knowledge-focused Not yet recruitingThis study will follow 300 adults who have both a portosystemic shunt (an abnormal blood vessel connection between the liver and the rest of the body) and pulmonary hypertension (high blood pressure in the lungs). Researchers want to learn more about how common this combination i…
Sponsor: Chinese Pulmonary Vascular Disease Research Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Scientists hunt for genes behind rare lung complication in liver bypass patients
Knowledge-focused Not yet recruitingThis study aims to find genetic variants that may explain why some people with a rare liver bypass condition (congenital portosystemic shunt) develop a serious lung complication called portopulmonary hypertension. Researchers will analyze blood samples from 120 patients and their…
Sponsor: Prof. Valérie Mc Lin • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC