Complex regional pain syndrome
MONDO:0019369A chronic pain syndrome characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.
Also known as: CRPS, algoneurodystrophy, reflex sympathetic dystrophy
197 clinical trials for this condition and its sub-types, 65 tagged with Complex regional pain syndrome itself.
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Sub-types of Complex regional pain syndrome
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Complex regional pain syndrome type 1 31 trials
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Complex regional pain syndrome type 2 18 trials
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Spinal cord stimulator may calm the 'fight or flight' system in chronic pain
Disease control Stopped earlyThis study investigates whether a spinal cord stimulator (SCS) alters the sympathetic nervous system — the body's fight-or-flight response — in people with Complex Regional Pain Syndrome (CRPS). Ten adults with CRPS will have their nerve activity, heart rate, and blood pressure m…
Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Pain drug lyrica put to the test for rare limb condition – but trial stalls
Symptom relief Stopped earlyThis study tested whether adding pregabalin (Lyrica) to standard treatment could reduce pain and improve function in people with complex regional pain syndrome (CRPS) of the upper limb. Only 14 adults were enrolled before the trial was stopped early. The goal was to see if the dr…
Sponsor: McMaster University • Aim: Symptom relief
Last updated Jun 27, 2026 13:08 UTC