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Spinal cord stimulator may calm the 'fight or flight' system in chronic pain

NCT ID NCT00780390

Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study investigates whether a spinal cord stimulator (SCS) alters the sympathetic nervous system — the body's fight-or-flight response — in people with Complex Regional Pain Syndrome (CRPS). Ten adults with CRPS will have their nerve activity, heart rate, and blood pressure measured before and after SCS implant. The goal is to see if changes in these measures can predict who gets the most pain relief from the device.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a spinal cord stimulator implant
What this could lead to
If it works, this could help doctors predict which CRPS patients will benefit most from a spinal cord stimulator before implanting it.
What could go wrong
This is a very small, early-stage study with only 10 participants. The results may not apply to all CRPS patients, and the stimulator implant carries surgical risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Start date

Jan 2008

Finished

Jan 2010

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * CRPS patients meeting the inclusion criteria according to the International Association for the Study of pain task Force will be included in the study. * Age: 18 to 65. * Disease duration of at least 6 months. * History of unsuccessful long lasting therapies: physical therapy, transcutaneous electrical stimulation and medication. Exclusion Criteria: * Presence of current or past pulmonary, hepatic, renal disease, arthritis, hematopoietic, and neurological diseases not related to CRPS. * Anticoagulant therapy, cardiac pacemaker used. * Pregnancy test for females is positive.

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Conditions

The condition(s) this trial relates to.

complex regional pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Complex regional pain syndrome

Contacts and locations

Locations

  • Vanderbilt University

    Nashville, Tennessee, 37212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.