Common variable immunodeficiency
MONDO:0015517Common variable immunodeficiency (CVID) comprises a heterogeneous group of diseases characterized by a significant hypogammaglobulinemia of unknown cause, failure to produce specific antibodies after immunizations and susceptibility to bacterial infections, predominantly caused by encapsulated bacteria.
Also known as: Common Variable Immune Deficiency, idiopathic immunoglobulin deficiency, primary antibody deficiency, primary hypogammaglobulinemia, secondary hypogammaglobulinemia, Immunoglobulin deficiency, late-onset, acquired agammaglobulinemia, acquired hypogammaglobulinemia
68 clinical trials for this condition and its sub-types, 29 tagged with Common variable immunodeficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Common variable immunodeficiency
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Immune deficiency, familial variable 0 trials
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Immunodeficiency, common variable, 1 0 trials
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1 sub-type
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Immunodeficiency, common variable, 2 0 trials
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Immunodeficiency, common variable, 3 0 trials
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Immunodeficiency, common variable, 4 0 trials
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Immunodeficiency, common variable, 5 0 trials
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Immunodeficiency, common variable, 6 0 trials
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Immunodeficiency, common variable, 7 0 trials
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New booster aims to shield the vulnerable from COVID-19
Vaccine CompletedThis study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…
Phase 2/3 • Sponsor: Hipra Scientific, S.L.U • Aim: Vaccine
Last updated Jun 26, 2026 18:38 UTC
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New drug shows promise for rare immune disorder in early trial
Disease control CompletedThis study tests a drug called leniolisib in 20 people with common variable immunodeficiency (CVID), a condition that weakens the immune system. All participants will receive the drug for 6 months, starting at a low dose and increasing. The main goal is to check safety and tolera…
Phase 2 • Sponsor: Pharming Technologies B.V. • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Gentler transplant shows promise for kids with blood diseases
Disease control CompletedThis study tests a milder chemotherapy and immune-suppressing regimen before a stem cell transplant for children and young adults with non-malignant blood disorders like sickle cell disease or immune deficiencies. The goal is to safely achieve donor cell engraftment with fewer si…
Phase 2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Can a simple ultrasound spot hidden liver danger in immune disorder patients?
Knowledge-focused CompletedThis study looked at whether ultrasound and stiffness measurements of the liver and spleen can predict a serious condition called portal hypertension in people with common variable immunodeficiency (CVID). Researchers examined 250 CVID patients during routine visits, using non-in…
Sponsor: University Hospital Freiburg • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Immune cell signals may unlock better CVID diagnosis
Knowledge-focused CompletedThis observational study compared blood samples from 24 people with antibody deficiency (CVID) and healthy volunteers. Researchers used advanced technology to measure how different immune cells respond to various triggers. The goal was to find patterns that could improve diagnosi…
Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC
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Scientists probe lung microbes in immune deficiency disorder
Knowledge-focused CompletedThis study looked at how common variable immunodeficiency (CVID) changes the bacteria and immune activity in the respiratory tract. Researchers collected samples from 75 people with and without CVID to analyze microbes and gene activity. The goal was to understand why lung proble…
Sponsor: Boston University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Scientists hunt for genetic clues in rare immune disease
Knowledge-focused CompletedThis study looked at 27 adults with a severe form of primary immunodeficiency, which causes frequent infections, enlarged lymph nodes, and low white blood cells. Researchers analyzed their DNA to find known and new genetic mutations linked to the condition. The goal was to better…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Do vaccines work as well in people with weak immune systems? new study investigates
Knowledge-focused CompletedThis study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…
Phase 4 • Sponsor: Centre Hospitalier Régional d'Orléans • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Hidden lung damage common in immune deficiency patients
Knowledge-focused CompletedThis completed study in France looked at how common bronchiectasis (permanent lung damage) is in 46 adults with primary humoral immunodeficiency, a condition that weakens the immune system. Participants had a chest CT scan and lung function tests to check for bronchiectasis. The …
Sponsor: CHU de Reims • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC