Clostridium difficile colitis
MONDO:0000705A bacterial infection of the colon secondary to infection with Clostridium difficile bacteria. This infection generally results from the loss of normal gut flora secondary to recent antibiotic use, and manifests as copious watery stools, with associated abdominal pain and myalgia. C. difficile is the most common cause of pseudomembranous colitis, and can progress to toxic megacolon if left untreated.
Also known as: C. diff colitis, C. diff infection, Clostridioides difficile caused colitis (disease), Clostridioides difficile colitis (disease), Clostridium difficile infection, pseudomembranous colitis
121 clinical trials for this condition and its sub-types, 69 tagged with Clostridium difficile colitis itself.
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New c. diff vaccine shows promise in preventing dangerous diarrhea
Vaccine OngoingThis study tests new versions of a vaccine to prevent severe diarrhea caused by the C. diff germ. Healthy adults aged 50 and older who have never had a C. diff infection will receive either a new vaccine formula, a previously studied formula, or a placebo. The goal is to see whic…
Phase 1/2 • Sponsor: Pfizer • Aim: Vaccine
Last updated Jun 27, 2026 12:24 UTC
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Poop pills for kids? new study tests fecal transplants against stubborn gut infections
Disease control By invitation onlyThis study tests whether a fecal transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give FMT to 250 children aged 3-21 and track whether the infection comes back.…
Phase 1 • Sponsor: Judith Kelsen • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Can an enzyme shield the gut during transplant recovery?
Disease control OngoingThis study tests an oral enzyme called SYN-004 in adults who have received a stem cell transplant and need intravenous antibiotics for fever. The enzyme is designed to break down antibiotics in the gut, protecting the natural bacteria there. Researchers will check safety, whether…
Phase 1/2 • Sponsor: Theriva Biologics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New drug aims to stop dangerous gut infection from returning
Prevention OngoingThis study tests an experimental drug called LMN-201 to see if it can prevent C. difficile infection from coming back after standard antibiotic treatment. About 375 adults with a recent C. diff infection will receive either LMN-201 or a placebo. The main goal is to see if more pe…
Phase 2/3 • Sponsor: Lumen Bioscience, Inc. • Aim: Prevention
Last updated Sep 13, 2026 00:00 UTC
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Old drug, new trick: vancomycin may stop c. diff before it starts
Prevention CancelledThis study tests whether taking oral vancomycin alongside other antibiotics can prevent Clostridioides difficile infection (C. diff) in people aged 65 and older. Participants are randomly assigned to receive either vancomycin or standard care. The goal is to see if the drug reduc…
Phase 2/3 • Sponsor: University of Maryland, Baltimore • Aim: Prevention
Last updated Jul 31, 2026 00:00 UTC
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Could your own poop prevent a deadly infection after transplant?
Prevention OngoingThis study tests whether giving patients their own preserved stool (collected before a stem cell transplant) can prevent Clostridium difficile infection afterward. About 59 adults receiving an allogeneic stem cell transplant are randomly assigned to get the stool transplant or st…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Prevention
Last updated Jun 27, 2026 07:58 UTC
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Could a simple drink help clear confusion in hospitalized seniors?
Symptom relief OngoingThis study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…
Sponsor: University of Arkansas • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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Furry friends fight gut bugs: study tests if pets shield against antibiotic side effects
Knowledge-focused OngoingThis study looks at whether having close contact with pets can help keep your gut healthy while taking antibiotics and lower the risk of a serious infection called C. difficile. Researchers will follow 200 adults getting dental implants who need antibiotics, checking their gut ba…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New database aims to speed up FMT research for gut infections
Knowledge-focused PausedThis study screens adults interested in fecal microbiota transplant (FMT) for Clostridium difficile infection. Researchers will collect medical information and run basic health tests to create a database of potential participants. The goal is to make it faster and easier to enrol…
Sponsor: Emory University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:39 UTC
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Hospital maps may slash infection spread
Knowledge-focused OngoingThis study tests a computer tool that uses maps and location data to help infection preventionists find and stop hospital-acquired infections faster. About 25 infection prevention staff will use the tool and report how easy it is to use and whether it helps them respond more quic…
Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC