Cleft lip
MONDO:0004747A congenital abnormality consisting of one or more clefts (splits) in the upper lip, which may be accompanied by a cleft palate; it is the result of the failure of the embryonic parts of the lip to fuse.
Also known as: cheiloschisis, cleft lip, cleft lip (disease), cleft lip, unilateral, complete, labium leporinum
32 clinical trials for this condition and its sub-types, 31 tagged with Cleft lip itself.
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Sub-types of Cleft lip
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Kuster syndrome 0 trials
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Rapp-Hodgkin syndrome 0 trials
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Isolated cleft lip 0 trials
2 sub-types
- Orofacial cleft 3 0 trials
- Orofacial cleft 5 0 trials
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New speech therapy approach may help children with cleft palate speak more clearly
Disease control By invitation onlyThis trial compares two speech therapy approaches for Cantonese-speaking children and teens aged 4 to 17 who have cleft palate with or without cleft lip. One method focuses on practicing individual sounds, while the other targets the overall sound system. The goal is to see which…
Sponsor: Chinese University of Hong Kong • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Custom-Shaped nose splint may ease recovery for kids after cleft lip surgery
Symptom relief By invitation onlyChildren who have cleft lip repair or nasal scar release often wear a nasal splint while healing. This trial compares the standard hollow, cone-shaped conformer with a new one shaped to match the inside of the nose. Each child tries both types, switching halfway through, and pare…
Phase 2 • Sponsor: East Tennessee Children's Hospital • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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Smart toothbrush trial for cleft surgery kids pulled before it started
Symptom relief CancelledThis study aimed to see if using a connected toothbrush (Ara® KOLIBREE) for one month before alveolar bone graft surgery could improve oral hygiene in children aged 5 to 12 with cleft lip and palate. The trial was withdrawn before enrolling any participants, so no results are ava…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Phone AI helps babies smile through surgery
Symptom relief OngoingThis study tests whether a smartphone-based AI tool can help doctors give a pain-blocking injection to babies having cleft lip repair. The goal is to reduce pain during surgery and the need for extra pain medicine. The study includes 120 infants aged 5-18 months and compares the …
Sponsor: Ain Shams University • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Cleft care network aims to boost outcomes by sharing data
Knowledge-focused By invitation onlyThis study brings together medical teams that treat children with cleft lip and/or palate. They will collect information on speech, hearing, dental health, and quality of life from about 1,000 patients. The goal is to compare results across centers and find ways to improve care. …
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC