Clear cell sarcoma

This study is for children and young adults (up to age 30) with a rare type of soft tissue cancer called non-rhabdomyosarcoma. It tests whether adding the drugs pazopanib and selinexor to standard chemotherapy can improve outcomes. Participants receive treatment tailored to their…

This study tests a special stem cell transplant for children, teens, and young adults (ages 6 months to 25 years) with solid tumors that have come back or not responded to treatment. The transplant uses cells from a donor, with certain immune cells removed to reduce side effects,…

This early-stage trial tests a new immunotherapy for children and young adults up to age 21 with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein…

This study tests an experimental oral drug called cirtuvivint for people with advanced soft-tissue sarcoma that has not responded to prior treatment. About 25 participants in Spain will take the drug to see if it can stop or slow cancer growth for at least 3 months. The drug targ…

This study tests a drug called tebentafusp in people with a rare and advanced type of cancer called clear cell sarcoma. Only patients with a specific genetic marker (HLA-A*02:01) can join. The goal is to see if the drug can stop the cancer from growing for at least 24 weeks. Abou…

This phase 2 trial tests the drug vebreltinib in 30 people with advanced clear cell sarcoma, a rare cancer of the soft tissues. Participants take the drug as a capsule twice daily until the cancer worsens or side effects become too severe. The main goal is to see if the drug can …

This study is collecting tumor and blood samples from 400 people with rare soft tissue sarcomas to learn how their immune system reacts to the cancer. Researchers will also track patients' health over time to see how the disease progresses. The goal is to find clues that could le…