Chronic granulomatous disease

MONDO:0018305

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency, mainly affecting phagocytes, which is characterized by an increased susceptibility to severe and recurrent bacterial and fungal infections, along with the development of granulomas.

Also known as: CGD, chronic septic granulomatosis, granulomatous disease, chronic

78 clinical trials for this condition and its sub-types, 37 tagged with Chronic granulomatous disease itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary disease (18187) ↑ Inflammatory disease (10833) ↑ Defective phagocytic cell engulfment (37) ↑ Phagocyte bactericidal dysfunction (37)

Sub-types of Chronic granulomatous disease

Granulomatous disease, chronic, X-linked 10 trials
Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 1 3 trials
Granulomatous disease with defect in neutrophil chemotaxis 0 trials
Granulomatous disease, chronic, autosomal recessive, 5 0 trials
Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative 0 trials
Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 2 0 trials
Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 3 0 trials

Including sub-types (78) Tagged with Chronic granulomatous disease (37)

Trials to join now! 38 Not yet recruiting 6 Not yet finished but already full! 18 Completed 14 Terminated 2

Experimental gene therapy aims to fix immune system in rare childhood disease

Disease control Stopped early

This early-phase trial tested a gene therapy for X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder that leaves boys unable to fight off bacteria and fungi. The treatment involved taking the patient's own blood stem cells, adding a corrected gene, and infusin…

Phase 1/2 • Sponsor: Genethon • Aim: Disease control

Last updated Jun 27, 2026 12:06 UTC
Experimental gene therapy targets rare immune disorder

Disease control Stopped early

This trial tested a gene therapy for X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder that leaves boys unable to fight off infections. The treatment involved taking the patient's own blood stem cells, adding a working copy of the faulty gene, and returning …

Phase 1/2 • Sponsor: Genethon • Aim: Disease control

Last updated Jun 27, 2026 12:06 UTC

Chronic granulomatous disease

Where it sits in the disease tree

Experimental gene therapy aims to fix immune system in rare childhood disease

Experimental gene therapy targets rare immune disorder