Chronic granulomatous disease

MONDO:0018305

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency, mainly affecting phagocytes, which is characterized by an increased susceptibility to severe and recurrent bacterial and fungal infections, along with the development of granulomas.

Also known as: CGD, chronic septic granulomatosis, granulomatous disease, chronic

78 clinical trials for this condition and its sub-types, 37 tagged with Chronic granulomatous disease itself.

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Where it sits in the disease tree

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↑ Hereditary disease (18187) ↑ Inflammatory disease (10833) ↑ Defective phagocytic cell engulfment (37) ↑ Phagocyte bactericidal dysfunction (37)

Sub-types of Chronic granulomatous disease

Including sub-types (78) Tagged with Chronic granulomatous disease (37)

Trials to join now! 16 Not yet recruiting 1 Not yet finished but already full! 13 Completed 5 Terminated 2

Gene fix for rare immune disease: can it stop deadly infections?

Disease control Not yet recruiting

This trial tests a gene therapy for chronic granulomatous disease (CGD), a rare immune disorder that leaves patients vulnerable to severe infections. Ten patients will receive their own stem cells modified with a lentivirus to correct the faulty gene. The goal is to restore immun…

Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control

Last updated Aug 28, 2026 00:00 UTC

Chronic granulomatous disease

Where it sits in the disease tree

Gene fix for rare immune disease: can it stop deadly infections?