Cholestasis
MONDO:0001751Impairment of the bile flow caused by obstruction within the liver, or outside the liver in the bile duct system.
Also known as: obstruction of bile duct
94 clinical trials for this condition and its sub-types, 44 tagged with Cholestasis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Cholestasis
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Biliary atresia 24 trials
3 sub-types
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Intrahepatic cholestasis 3 trials · 24 incl. sub-types
2 sub-types
- Familial intrahepatic cholestasis 1 trial · 17 incl. sub-types Sub-types →
- Intrahepatic cholestasis of pregnancy 6 trials Sub-types →
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Obstructive jaundice 11 trials
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Extrahepatic cholestasis 0 trials
1 sub-type
- Mirizzi syndrome 0 trials
Most studied deeper sub-types
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Can a common antioxidant help babies with a rare liver disease? first safety trial begins
Symptom relief Not yet recruitingThis early-phase study tests whether infants with biliary atresia can tolerate oral N-Acetylcysteine (NAC) mixed into applesauce. Twelve infants will first receive plain applesauce, then NAC at increasing doses. The goal is to see if they can keep the medicine down without vomiti…
Phase 1 • Sponsor: Sanjiv Harpavat • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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New hope for Moms-to-Be: drug targets dangerous pregnancy itch
Symptom relief Not yet recruitingThis early-stage study tests a drug called maralixibat in 28 pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes severe itching and high bile acids. The main goal is to see if the drug is safe and tolerable for both mother and baby. Rese…
Phase 2 • Sponsor: Imperial College London • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Hidden heart risks in babies with liver disease
Knowledge-focused Not yet recruitingThis study will examine 106 infants under two years old who have cholestasis (a liver condition) to see how many also have congenital heart defects and how their development is affected. Researchers will use echocardiograms and developmental assessments. The goal is to better und…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC