Cholestasis

This study tests whether adding calcitriol to vitamin D2 helps children with cholestatic liver disease correct their vitamin D deficiency faster than vitamin D2 alone. Cholestasis makes it hard for the body to absorb vitamin D. The trial will enroll 54 children and track vitamin …

This study looks at two types of metal stents (partially covered vs. bare) used to open blocked bile ducts in people with incurable cancer. The goal is to see which stent keeps the duct open longer and causes fewer problems. Sixty adults who already have a drainage tube will be r…

This study tracks up to 30 adults who need an endoscopic ultrasound (EUS) procedure using a new device called RIVOS. The device helps doctors access and treat problems like fluid collections, blockages, or chronic pancreatitis. Researchers will measure how often the procedure wor…

This study follows about 200 people who receive a special stent that naturally dissolves over time to open blocked bile or pancreatic ducts. The stent is designed to avoid the need for a second procedure to remove it. Researchers track safety and how well the stent keeps the duct…

This study follows 230 children with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC) who are taking Livmarli, a drug to reduce bile buildup and itching. Researchers will monitor side effects, liver function, and long-term outcomes like need for transplan…

This study tests a new stent that slowly dissolves over time to open narrowed or blocked bile ducts. About 100 people with bile duct strictures will receive the stent during a routine procedure. Researchers will track safety, how well the stent works, and whether patients feel be…

This study tests whether a high-energy liquid formula with added vitamins can improve nutrition in children under 5 who have chronic cholestasis (a liver condition that blocks bile flow) and severe malnutrition. Fifteen children will drink the formula for 14 days, and researchers…

This study tests whether giving an antibiotic (gentamicin) directly into the bile duct during a procedure called ERCP helps people with acute cholangitis recover faster. About 172 adults with mild to moderate infection will be randomly assigned to receive either the extra antibio…

This study tests a new drug, LB-P8, in 87 adults with primary sclerosing cholangitis (PSC), a rare liver disease. The goal is to see if LB-P8 is safe and can lower levels of alkaline phosphatase (ALP), a marker of liver damage. Participants will receive either LB-P8 or a placebo,…

This study explores whether a computer program can learn to spot signs of cholestasis—a liver condition where bile flow is blocked—by analyzing photos of dirty diapers taken by parents. Researchers will collect images from thousands of infants, both healthy and those with suspect…

This study tests a simple method to diagnose biliary atresia, a serious liver condition in newborns. Infants with suspected cholestasis receive a dye called indocyanine green (ICG) through an IV. Doctors then check the baby's diaper for the dye, which would indicate bile is flowi…

This study compares two types of sedation used during a procedure to drain blocked bile ducts. About 98 adults will receive either propofol-remifentanil or propofol-ketamine. The goal is to see which method leads to faster recovery, better comfort, and fewer side effects, especia…

This study tests two methods for widening a blocked bile duct during a special endoscopy procedure. One method uses a mechanical dilator, the other uses an electrocautery device. The goal is to see which causes less bleeding. The trial will involve 64 patients who cannot have sta…

This study looks at how the drug Saroglitazar is processed in people with mild, moderate, or severe liver scarring (cirrhosis) caused by cholestatic liver disease. About 30 adults will take the drug once daily for 28 days. The goal is to measure drug levels in the blood and check…

This early-stage study will test a drug called saroglitazar magnesium in 6 adults with moderate liver scarring (cirrhosis) caused by cholestatic liver disease. The main goal is to see how the drug moves through the body and if it is safe when taken every other day. Participants w…

This study is collecting medical information, genetic material, and body fluid samples from over 1,200 children with biliary atresia, a rare liver disease. The goal is to find genes that cause the disease and understand how it progresses in children who still have their own liver…

This study creates a Canadian registry for children under 18 with Alagille syndrome or genetic intrahepatic cholestasis, rare liver conditions that cause bile buildup. Researchers will collect health data from medical records over time to understand how these diseases progress an…

This registry will follow 510 adults undergoing therapeutic endoscopic ultrasound (EUS) for conditions like stomach or bile duct blockages, pancreatic fluid collections, or gallbladder inflammation. The goal is to see how well these procedures work over the long term and what fac…

This study is using advanced whole-genome sequencing to find hidden genetic causes of cholestatic liver disease in adults whose condition remains unexplained after standard tests. Researchers will compare the DNA of 60 affected adults to a large group of healthy controls. The goa…

This study aims to collect medical history, family history, and blood or urine samples from 10,000 people with or at risk for pancreatic cancer. Researchers will use this information to look for genetic and environmental factors linked to the disease. Participants may also be ask…