Childhood eosinophilic esophagitis

This pilot study looks at whether children with eosinophilic esophagitis (EoE) can safely eat heated forms of cow's milk and hen's egg without their disease coming back. Researchers will gradually introduce less heated versions to see if tolerance can be built. The trial involves…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This study tests a magnetically controlled capsule endoscope—a tiny camera you swallow—to painlessly screen the esophagus and stomach. Researchers will compare different swallowing protocols to see which gives the best view of the Z-line and other areas. 300 patients already sche…

This study follows children aged 2-17 with eosinophilic gastrointestinal disorders (EGID) to see how elimination diets—removing foods like milk, eggs, or wheat—affect their symptoms and gut healing. Doctors choose the diet as part of routine care, and researchers track clinical a…

This trial asks whether single-use gastroscopes work as well as standard reusable ones for elective and subacute upper GI procedures. About 300 adults will be examined with either a disposable or a reusable scope, and endoscopists will rate performance on a questionnaire. The stu…

This study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…