Childhood acute lymphoblastic leukemia

This study tested whether removing a specific type of immune cell (naïve T cells) from donor stem cell grafts could prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial enrolled 84 patients who received high- or medium-intensity chemo…

This pilot study tested whether giving critically ill children on breathing machines extra protein along with a personalized exercise program could help preserve muscle mass and improve recovery. The trial enrolled 18 children in the ICU and measured how feasible and safe the app…

This early-phase trial tested whether a new type of immune cell therapy (CD22 CAR T cells) could be safely made and given to 10 children and young adults whose B-cell leukemia or lymphoma had come back or stopped responding to treatment. The therapy uses the patient's own immune …

This early-phase study tested whether adding the targeted drug palbociclib to standard chemotherapy is safe for children with acute lymphoblastic leukemia that has returned or not responded to treatment. Only 2 children took part, and the main goal was to find the highest tolerab…

This study tested a two-step stem cell transplant for people with blood cancers like leukemia and lymphoma. First, patients received low-dose chemotherapy and radiation to prepare their bodies. Then, they got donor stem cells followed by drugs to prevent the donor cells from atta…

This pilot study tested a liposomal form of the chemotherapy drug vincristine (Marqibo) combined with standard UK ALL R3 chemotherapy in 29 children, adolescents, and young adults with relapsed acute lymphoblastic leukemia. The main goal was to see if it was safe and tolerable at…

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This study tested whether sending text message reminders to parents could increase routine vaccination rates in children aged 0-2 years. Over 1,000 families in Brooklyn, New York, whose children were behind on vaccines received texts when shots were due or coming due. The goal wa…

This trial tests whether a local anesthetic injection (ropivacaine) can keep children aged 6 to 12 awake and comfortable during upper limb surgery, avoiding general anesthesia. Children watch cartoons on a tablet for distraction while the anesthetic is given. The study aims to se…

This study tests whether giving sugammadex (a drug that reverses muscle relaxants) can lower the chance of children waking up agitated after strabismus (eye muscle) surgery. About 76 children aged 4 to 7 will be randomly assigned to receive either sugammadex or a standard drug (n…

This study is testing a new type of prosthetic leg for children aged 3 to 18 that can be easily adjusted as they grow. The device is designed to be fitted in a single session and adjusted by the wearer. Researchers will measure comfort, socket pressure, walking speed, and quality…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested whether a robotic baby harp seal could help children aged 5-18 feel less anxious and more motivated during physical or occupational therapy in the hospital. Twenty-five kids used the robot during their sessions, and researchers measured their pain, anxiety, and …

This study tested if playing an augmented reality game called SpellBound can help children with cancer feel less pain and need fewer opioids after surgery. 29 kids aged 5-15 who had never taken opioids before took part. The game was used alongside standard care to see if it impro…

This study tested a web-based program to help children aged 8-17 with cancer adjust to returning to school. The program included modules for children, parents, teachers, and peers, focusing on communication, coping, and social skills. Twenty children participated, and researchers…

This study tested whether 8 weeks of respiratory muscle training using a special breathing device could improve lung function and muscle strength in 30 children aged 8-18 who had a kidney transplant at least 6 months earlier. The training involved both inspiratory and expiratory …

This study is translating and testing a Turkish version of the Hammersmith Neonatal Neurological Examination (HNNE) for high-risk infants, such as premature babies or those with birth complications. Researchers will check if the exam is reliable and valid for use in Turkey by com…

This study looked back at the medical records of 57 children and young adults (under 25) who received CAR T-cell therapy for B-cell acute lymphoblastic leukemia (B-ALL). The goal was to understand how well the treatment worked and what side effects occurred, especially in those w…

This study looked at 583 children who had liver transplants and later developed narrowing or blockage of the liver artery. Researchers wanted to find out how common these problems are and what treatments work best. The goal is to improve care and outcomes for future patients.

This study looked at 148 children with T-cell acute lymphoblastic leukemia to see if a high-tech gene test could find tiny amounts of cancer left after treatment. Researchers used next-generation sequencing to check for specific gene changes in immune cells. They then compared th…

This study looked at a different way to help children breathe during surgery. Instead of placing the breathing tube all the way into the windpipe, doctors placed it just above the vocal cords. The goal was to see if this method is easy, safe, and works well. The study included 85…

This study looked at whether a new educational program helps doctors-in-training better recognize and respond to child maltreatment. 84 medical residents from Canadian universities took part. The program was delivered either in a group with a leader or on their own. The goal was …

This study tested a virtual reality (VR) afterschool program for 32 children ages 9-17. The goal was to see if kids would use and enjoy the VR system, and to measure their physical activity. This was a pilot study to gather information, not to treat or cure any disease.

This completed trial compared two ways to start CPR in a simulated child cardiac arrest: starting with chest compressions (AHA method) versus starting with rescue breaths (ERC method). Researchers used a manikin to measure how much air reached the lungs in the first minute. 28 he…

This completed study looked at how well parents of infants with early eczema and parents of healthy infants could use a mobile-friendly platform called OneBiome. The platform gives reports on the baby's gut microbiome and eating patterns. Researchers wanted to see if parents foun…

This study followed 89 children who finished chemotherapy for acute lymphoblastic leukemia (ALL) to see how their immune systems bounced back. Researchers measured antibody levels for vaccine-preventable diseases and tracked infections during the first year off treatment. The goa…

This study compared two types of liquid food (Pediasure and Nourish) to see how they affect the gut bacteria in 32 critically ill children ages 1-17 in the ICU. Researchers collected stool and saliva samples to track changes in the microbiome. The goal was to understand how diffe…

This study tested whether a device called the ANI monitor can measure pain in sedated children aged 2 and older in the pediatric intensive care unit. Researchers watched how the device responded during painful care and compared it to a standard behavioral pain scale. The goal was…

This study tested a new service that lets parents call for medical help at night and get medicine delivered to their home for their sick children. Over 1,200 children with common illnesses like pneumonia, diarrhea, or malaria took part in three communities in Ghana. The goal was …