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Engineered immune cells take aim at tough childhood cancers

NCT ID NCT04088864

First seen Jun 02, 2026 · Last updated Jun 14, 2026 · Updated 2 times

Summary

This early-phase trial tested whether a new type of immune cell therapy (CD22 CAR T cells) could be safely made and given to 10 children and young adults whose B-cell leukemia or lymphoma had come back or stopped responding to treatment. The therapy uses the patient's own immune cells, modified to target a protein called CD22 on cancer cells. The main goals were to see if the cells could be successfully produced and to find a safe dose, while also checking for any cancer-fighting effects.

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Contacts and locations

Locations

  • Stanford Medical Center

    Stanford, California, 94304, United States

Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia B-cell non-Hodgkin lymphoma Lymphoma Lymphoma, B-Cell Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.